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Chelee · 11-09-2010, 03:57 AM

DeenaH,
This is just a wild quess on my part but I think some weren't offered the Tykerb/Herceptin combo because it wasn't an approved combo till this last yr or so? When I had a recurrence last yr in 09 I went out to see Dr. Slamon. He recommended Tykerb/Herceptin. After seeing Dr. Slamon I saw two other onc's with good reputations and both of them told me Dr. Slamon was wrong...that I "had" to add a chemo for Tykerb/Herceptin to work. They were both adamant about it.

I called UCLA up and told them what I was being told and was reassured me that this combo works great. Not long after that it came out at that yrs ASCO conference that it was now an approved combo with good results. Some of these onc's are just not up to date it seems on alot of the newer drugs and combo's. UCLA as you know is cutting edge! So that is my theory on why many of these ladies weren't offered Tykerb first. Many onc's don't even know this combo works. Hopefully some will chime in.

Chelee

11-09-2010, 03:57 AM	#98
Chelee Senior Member Join Date: Feb 2006 Location: Southern, CA Posts: 2,511	Re: Neratinib Clinical Trial DeenaH, This is just a wild quess on my part but I think some weren't offered the Tykerb/Herceptin combo because it wasn't an approved combo till this last yr or so? When I had a recurrence last yr in 09 I went out to see Dr. Slamon. He recommended Tykerb/Herceptin. After seeing Dr. Slamon I saw two other onc's with good reputations and both of them told me Dr. Slamon was wrong...that I "had" to add a chemo for Tykerb/Herceptin to work. They were both adamant about it. I called UCLA up and told them what I was being told and was reassured me that this combo works great. Not long after that it came out at that yrs ASCO conference that it was now an approved combo with good results. Some of these onc's are just not up to date it seems on alot of the newer drugs and combo's. UCLA as you know is cutting edge! So that is my theory on why many of these ladies weren't offered Tykerb first. Many onc's don't even know this combo works. Hopefully some will chime in. Chelee __________________ DX: 12-20-05 - Stage IIIA, Her2/Neu, 3+++,Er & Pr weakly positive, 5 of 16 pos nodes. Rt. MRM on 1-3-06 -- No Rads due to compromised lungs. Chemo started 2-7-06 -- TCH - - Finished 6-12-06 Finished yr of wkly herceptin 3-19-07 3-15-07 Lt side prophylactic simple mastectomy. -- Ooph 4-05-07 9-21-09 PET/CT "Recurrence" to Rt. axllia, Rt. femur, ilium. Possible Sacrum & liver? Now stage IV. 9-28-09 Loading dose of Herceptin & started Zometa 9-29-09 Power Port Placement 10-24-09 Mass 6.4 x 4.7 cm on Rt. femur head. 11-19-09 RT. Femur surgery - Rod placed 12-7-09 Navelbine added to Herceptin/Zometa. 3-23-10 Ten days of rads to RT femur. Completed. 4-05-10 Quit Navelbine--Herceptin/Zometa alone. 5-4-10 Appt. with Dr. Slamon to see what is next? Waiting on FISH results from femur biopsy. Results to FISH was unsuccessful--this happens less then 2% of the time. 7-7-10 Recurrence to RT axilla again. Back to UCLA for options.