HER2 Support Group Forums - View Single Post - Cox2 and her-2

R.B. · 08-20-2008, 06:32 AM

Hi Full of Beans,

Omega six is the raw material.

COX 2 is an enzyme that is part of the conversion process to prostaglandins. COX 2 products are made on demand as a result of requests received as chemical messengers triggered by a perceived need for inflammatory chemicals - things to mend immune threat etc.

Prostaglandins have a role in controlling aromatase and other enzymes involved in making sex hormones.

So no raw material, and COX 2 has nothing to help convert. Less Omega 6 must in the long term subject to body fat stores mean less downstream Omega 6 based inflammatory products.

Omega 3 also uses COX2 to make its own products. So more Omega 3 and some of the COX2 available production capacity will be diverted to Omega 3 products.

DHA also block the COX2 Omega 6 production line.

Drugs do the same thing by blocking COX2 from working. Clearly drugs can provide immediate relief but cannot remove excess omega six from the diet. Arguably the starting point of a long term strategy has to be sorting out the Omega 3 6 balance, and trials show doing that helps relieve inflammation and may reduce or for some even maybe eliminate the need for related drugs.

Is aromatase the only factor. Clearly no. In the greek diet thread there are a number of pathways connected to BC that respond to the Omega 3:6 balance. http://her2support.org/vbulletin/sho...ght=greek+diet

The body is enormously complex so there are another factors too but excess Omega 6 and lack of 3 are a risk factor people can do something about and the risk reduction figures are suggest to be anything from 70% down depending on what trial you look at..

Clearly we are all different so please discuss dietary change with your Doctor and more so if on medication so you can properly assess plan and monitor.

08-20-2008, 06:32 AM	#4
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Hi Full of Beans, Omega six is the raw material. COX 2 is an enzyme that is part of the conversion process to prostaglandins. COX 2 products are made on demand as a result of requests received as chemical messengers triggered by a perceived need for inflammatory chemicals - things to mend immune threat etc. Prostaglandins have a role in controlling aromatase and other enzymes involved in making sex hormones. So no raw material, and COX 2 has nothing to help convert. Less Omega 6 must in the long term subject to body fat stores mean less downstream Omega 6 based inflammatory products. Omega 3 also uses COX2 to make its own products. So more Omega 3 and some of the COX2 available production capacity will be diverted to Omega 3 products. DHA also block the COX2 Omega 6 production line. Drugs do the same thing by blocking COX2 from working. Clearly drugs can provide immediate relief but cannot remove excess omega six from the diet. Arguably the starting point of a long term strategy has to be sorting out the Omega 3 6 balance, and trials show doing that helps relieve inflammation and may reduce or for some even maybe eliminate the need for related drugs. Is aromatase the only factor. Clearly no. In the greek diet thread there are a number of pathways connected to BC that respond to the Omega 3:6 balance. http://her2support.org/vbulletin/sho...ght=greek+diet The body is enormously complex so there are another factors too but excess Omega 6 and lack of 3 are a risk factor people can do something about and the risk reduction figures are suggest to be anything from 70% down depending on what trial you look at.. Clearly we are all different so please discuss dietary change with your Doctor and more so if on medication so you can properly assess plan and monitor. Last edited by R.B.; 08-20-2008 at 06:38 AM..