HER2 Support Group Forums - View Single Post - ARRY-520: KSP inhibitor

Rich66 · 05-05-2009, 10:17 AM

http://www.businesswire.com/portal/s...27&newsLang=en

ARRY-543 - ErbB-2 / EGFR inhibitor for solid tumors: Array continued its Phase 1b trial of ARRY-543 in combination with Xeloda® (capecitabine) in patients with solid tumors. Array initiated two additional Phase 1b trials, in combination with Taxotere® (docetaxel) and Gemzar® (gemcitabine).
AACR Highlights: Preliminary results presented on Array’s Phase 1 trial showed that ARRY-543 was generally well-tolerated and demonstrated evidence of tumor regression and prolonged stable disease in EGFR- and ErbB2-expressing cancers. Of the confirmed patients with ErbB2-positive metastatic breast cancer treated with ARRY-543, 63 percent achieved stable disease for 16 weeks or longer. Twenty one patients were evaluated: 12 had available biopsies and eight were confirmed ErbB2-positive. Clinical benefit was demonstrated in five of these eight patients and patients with confirmed co-expression of ErbB2 and EGFR tended to have the best clinical benefit. In patients with other cancers shown to express ErbB family members, three patients, with ovarian cancer, cervical cancer and cholangiocarcinoma, respectively, treated with ARRY-543 also achieved stable disease for 16 weeks or more; the patient with cholangiocarcinoma experienced a tumor marker response that was accompanied by a 25 percent regression of target lesions.

ARRY-380 – ErbB-2 inhibitor for cancer: Patient recruitment in a Phase 1 trial of ARRY-380, an oral, selective ErbB-2 inhibitor, remains on track to complete in 2009. The trial is designed to evaluate the safety, maximum tolerated dose, and pharmacokinetics of ARRY-380 in cancer patients.

05-05-2009, 10:17 AM	#2
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	http://www.businesswire.com/portal/s...27&newsLang=en ARRY-543 - ErbB-2 / EGFR inhibitor for solid tumors: Array continued its Phase 1b trial of ARRY-543 in combination with Xeloda® (capecitabine) in patients with solid tumors. Array initiated two additional Phase 1b trials, in combination with Taxotere® (docetaxel) and Gemzar® (gemcitabine). AACR Highlights: Preliminary results presented on Array’s Phase 1 trial showed that ARRY-543 was generally well-tolerated and demonstrated evidence of tumor regression and prolonged stable disease in EGFR- and ErbB2-expressing cancers. Of the confirmed patients with ErbB2-positive metastatic breast cancer treated with ARRY-543, 63 percent achieved stable disease for 16 weeks or longer. Twenty one patients were evaluated: 12 had available biopsies and eight were confirmed ErbB2-positive. Clinical benefit was demonstrated in five of these eight patients and patients with confirmed co-expression of ErbB2 and EGFR tended to have the best clinical benefit. In patients with other cancers shown to express ErbB family members, three patients, with ovarian cancer, cervical cancer and cholangiocarcinoma, respectively, treated with ARRY-543 also achieved stable disease for 16 weeks or more; the patient with cholangiocarcinoma experienced a tumor marker response that was accompanied by a 25 percent regression of target lesions. ARRY-380 – ErbB-2 inhibitor for cancer: Patient recruitment in a Phase 1 trial of ARRY-380, an oral, selective ErbB-2 inhibitor, remains on track to complete in 2009. The trial is designed to evaluate the safety, maximum tolerated dose, and pharmacokinetics of ARRY-380 in cancer patients.