fatigue , nausea, is not as bad as older chemos like taxanes, adria etc. , and those s/e diminish for many as body adjusts. look at Lorraine after 40 doses or so, over 3 yrs - filmed in arizona testifying for right to try laws this past spring - after flying the ' redeye ' to phoenix from boston the night before :
http://youtu.be/AkQOLGpXf98 she does get tired but works pt, exercises, watches our grandchildren weekly. the quality of life on this drug is as revolutionary as its cancer killing power. good luck, God Bless.