HER2 Support Group Forums - View Single Post - Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastases)

Rolepaul · 05-15-2014, 01:37 PM

Pretty interesting as TDM-1 has a molecule that might allow blood brain barrier penetration. It is not good for direct input into the cavity (though an Ommaya reservoir or lumbar puncture) but IV appears to have some benefit. The goal right now is to get IT Herceptin and Perjeta going in clinical trials.

We are on the edge of making this disease go into remission for many women. I just want to say that many of us in the industry want this to occur as soon as possible.

05-15-2014, 01:37 PM	#169
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 389	Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase Pretty interesting as TDM-1 has a molecule that might allow blood brain barrier penetration. It is not good for direct input into the cavity (though an Ommaya reservoir or lumbar puncture) but IV appears to have some benefit. The goal right now is to get IT Herceptin and Perjeta going in clinical trials. We are on the edge of making this disease go into remission for many women. I just want to say that many of us in the industry want this to occur as soon as possible.