HER2 Support Group Forums - View Single Post - flaxseed lignans inhibit estradiol induced growth, angiogenesis, and VEGF secretion

Lani · 02-14-2007, 09:56 PM

whether whole flaxseeds have beneficial or deleterious effects on her2+er+ breast cancer. The oil seems to have anti her2 effects, but the seed itself seems to have phytoestrogens which might stimulate growth. The closest cell line to approximate the tumors of her2+ER+patients' tumors is BT474.

This seemed to show that the lignans themselves had antiestrogenic effects on MCF7 (her2 negative) cell line cells--but whether that is counterbalanced by the phytoestrogens or whether the effect would be the same in BT474 does not seem to have been studied yet.

I would love to hear otherwise. Anyone?

02-14-2007, 09:56 PM	#3
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	I remember that--what I was looking for is whether whole flaxseeds have beneficial or deleterious effects on her2+er+ breast cancer. The oil seems to have anti her2 effects, but the seed itself seems to have phytoestrogens which might stimulate growth. The closest cell line to approximate the tumors of her2+ER+patients' tumors is BT474. This seemed to show that the lignans themselves had antiestrogenic effects on MCF7 (her2 negative) cell line cells--but whether that is counterbalanced by the phytoestrogens or whether the effect would be the same in BT474 does not seem to have been studied yet. I would love to hear otherwise. Anyone?