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Rich66 · 03-31-2009, 07:04 PM

1: J Vasc Interv Radiol. 2009 Mar 26. [Epub ahead of print] Links: Radiation Lobectomy-A Minimally Invasive Treatment Model for Liver Cancer: Case Report.

Siddiqi NH, Devlin PM.
Division of Vascular and Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110.
Chemotherapy-resistant colon carcinoma metastases to a patient's right hepatic lobe progressed after right lobar radioembolization with yttrium-90. The metastasis-free left lobe had adequate volume as a future liver remnant. Repeat right lobar radioembolization with supratherapeutic activity of (90)Y caused shrinking of the tumors and the right lobe with no adverse outcome. With an adequate tumor-free future liver remnant, one hepatic lobe bearing a large tumor burden may be administered supratherapeutic activity of (90)Y, risking lobar ablation for greater probability of tumor eradication. This is analogous to hepatic lobectomy. This case is presented as a proof of principle.
PMID: 19328722 [PubMed - as supplied by publisher

03-31-2009, 07:04 PM	#1
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Radiation Lobectomy-A Minimally Invasive Treatment Model for Liver Cancer 1: J Vasc Interv Radiol. 2009 Mar 26. [Epub ahead of print] Links Radiation Lobectomy-A Minimally Invasive Treatment Model for Liver Cancer: Case Report. Siddiqi NH, Devlin PM. Division of Vascular and Interventional Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110. Chemotherapy-resistant colon carcinoma metastases to a patient's right hepatic lobe progressed after right lobar radioembolization with yttrium-90. The metastasis-free left lobe had adequate volume as a future liver remnant. Repeat right lobar radioembolization with supratherapeutic activity of (90)Y caused shrinking of the tumors and the right lobe with no adverse outcome. With an adequate tumor-free future liver remnant, one hepatic lobe bearing a large tumor burden may be administered supratherapeutic activity of (90)Y, risking lobar ablation for greater probability of tumor eradication. This is analogous to hepatic lobectomy. This case is presented as a proof of principle. PMID: 19328722 [PubMed - as supplied by publisher