[Laurel]

Gosh, Flori, how do you decide? Paul's information should lend some clarity for you. At least I hope it does! I do respect the information, and value Juls' resignation that at the end of the day it will fall to you and your "gut" to decide.

Ok. Here are my two, probably worthless cents, but I think if I were in your shoes I'd fight for the Kadcyla strickly based upon the better the devil you know philosophy. Perhaps it will go well for you and you will have a long run with it. By the time it ends something else will arrive for you to try. Hope blooms eternal and you do have 2 treatment prospects before you to have hope in.

Flori, I cannot remember or ascertain from your signature; have you ever done TDM1?

Sorry, that was all a bit rambling. Summation: I wish to high heaven I had a crystal ball because then I'd be truly dangerous & would advise you will the utmost confidence! I will lift you up in prayer, my friend. It is not "all we can do;" it is everything we can do and an honor.