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R.B. · 07-25-2019, 03:54 AM

Role of Dietary Fat in Ultraviolet Light–Induced Carcinogenic Expression J Integr Oncol 2014, Vol 3(2): e107 DOI: 10.4172/2329-6771.1000e107

Open PDF
https://www.omicsonline.org/open-acc...1.1000e107.pdf

Thought provoking as to the role of fat in cancer - much we do not know - the sadness is there is significant evidence and biology pointing to a role for excess Omega 6 in the context of an antioxidant depleted pre-oxidised processed diet being a significant potential factor in cancer risk of onset and progression - yet robust follow up studies to this old research has never been done so far as I know.

Type of fat is clearly a factor, there are no reports of significant levels of cancer in Inuit, and a study using coconut fat compared to vegetable fats in rodents resulted in low initiation and progression in the coconut oil group. Also as observed in this review "Reeve et al. [8] found that feeding a diet supplying totally saturated sunflower oil (hydrogenated) completely abolished the UVL carcinogenic response, whereas those animals receiving the polyunsaturated sunflower oil exhibited 100% tumor incidence". once the structure of the linoleic acid was changed to that of a saturated fat it no longer had the same carcinogenic effect - so it is not just about quantity of fat . . .

About melanoma, but discussing role of fats in cancer, and interestingly discussing the possible role of Omega 6 linoleic acid which forms ~ 3-4% of butter fats and 50-70% of some vegetable oils (butter fat presumably also contain conjugated linoleic acid).

Abstract
"A considerable body of evidence has accrued that indicates the influence of omega-6,-3 PUFA on UVL carcinogenesis is predicated upon the differential metabolites of the cyclooxygenase pathway [19].The different effects upon UVL carcinogenic expression, the differences in eicosanoid intermediates, the differences in immune responsiveness of omega-6 and omega-3 PUFA precludes the general indictment of dietary PUFA in cancer risk and this recommendation must be refined, based on individual PUFA [23]. In summary, the implementation of a low-fat diet and omega-3 supplementation show the greatest promise as dietary strategies for the management and prevention of the highly prevalent NMSC"

(apologies for not updating more often but not enough hours in the day - working on two books and a long paper at the moment)

07-25-2019, 03:54 AM	#436
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. Role of Dietary Fat in Ultraviolet Light–Induced Carcinogenic Expression J Integr Oncol 2014, Vol 3(2): e107 DOI: 10.4172/2329-6771.1000e107 Open PDF https://www.omicsonline.org/open-acc...1.1000e107.pdf Thought provoking as to the role of fat in cancer - much we do not know - the sadness is there is significant evidence and biology pointing to a role for excess Omega 6 in the context of an antioxidant depleted pre-oxidised processed diet being a significant potential factor in cancer risk of onset and progression - yet robust follow up studies to this old research has never been done so far as I know. Type of fat is clearly a factor, there are no reports of significant levels of cancer in Inuit, and a study using coconut fat compared to vegetable fats in rodents resulted in low initiation and progression in the coconut oil group. Also as observed in this review "Reeve et al. [8] found that feeding a diet supplying totally saturated sunflower oil (hydrogenated) completely abolished the UVL carcinogenic response, whereas those animals receiving the polyunsaturated sunflower oil exhibited 100% tumor incidence". once the structure of the linoleic acid was changed to that of a saturated fat it no longer had the same carcinogenic effect - so it is not just about quantity of fat . . . About melanoma, but discussing role of fats in cancer, and interestingly discussing the possible role of Omega 6 linoleic acid which forms ~ 3-4% of butter fats and 50-70% of some vegetable oils (butter fat presumably also contain conjugated linoleic acid). Abstract "A considerable body of evidence has accrued that indicates the influence of omega-6,-3 PUFA on UVL carcinogenesis is predicated upon the differential metabolites of the cyclooxygenase pathway [19].The different effects upon UVL carcinogenic expression, the differences in eicosanoid intermediates, the differences in immune responsiveness of omega-6 and omega-3 PUFA precludes the general indictment of dietary PUFA in cancer risk and this recommendation must be refined, based on individual PUFA [23]. In summary, the implementation of a low-fat diet and omega-3 supplementation show the greatest promise as dietary strategies for the management and prevention of the highly prevalent NMSC" (apologies for not updating more often but not enough hours in the day - working on two books and a long paper at the moment) Last edited by R.B.; 07-25-2019 at 03:01 PM..