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Feb 2012: diagnosed with 1 cm lesion rt breast, DCIS left breast, Stage IV ER+/HER2+
Apr 2012: bilateral partial excisions; confirmed met to left proximal femur, long gamma nail inserted to stabilize femur:
May 2012: radiation to femur: chemo with Trastuzumab + taxane.
July 2012 thru Mar 2015: started maintenance regime Herceptin+Arimidex+Denosumab, NED
May 2014: recurrence in right acetabulum: 15 fractions radiation
Jan 2015: lesion in left cerebellum: resection & gamma knife treatment
Mar 2015: major general progression; small mets confirmed in rt axilla, rt breast, T7 vertebra, possible met as isolated spiculated pulmonary nodule left lung[LIST][*]27 Mar 2015: start Kadcyla, discontinue aromotase inhibitors; within two weeks axilla/rt breast lesions are shrinking noticeably[*]18 April: resume letrozole [*]May: all lesions disappeared or dormant[*]June - discontinue Kadcyla due to low platelets[*]Aug & Nov 2015 MRI brain/spinal scans all negative for CNS disease: no recurrence to date
Fall 2015 - stereotactic radiation to lingering T3 lesion to relieve pain; 90% effective within weeks
July 2019 - discontinued Letrozole due to side effects
April 2020 - short course steretactic radiation to 2 cm lesion in upper left lung; subsequent scan finds it reduced
Mar 2021 - 6.5 cm mass found in left lung; FISH finds it is PR-, ER- and strongly HER2+.
16 April 2021 - Resume Kadcyla.

04-04-2015, 07:22 PM	#19
vqtilley Member Join Date: Mar 2015 Posts: 13	Re: Kadcyla Side Effects Thanks so much, Karina, I'd be really interested to read the article but the link doesn't work and Google/Google Scholar searches on the title only bring up the abstract with no free full text option. Any tips on where the full text might be available? __________________ Feb 2012: diagnosed with 1 cm lesion rt breast, DCIS left breast, Stage IV ER+/HER2+ Apr 2012: bilateral partial excisions; confirmed met to left proximal femur, long gamma nail inserted to stabilize femur: May 2012: radiation to femur: chemo with Trastuzumab + taxane. July 2012 thru Mar 2015: started maintenance regime Herceptin+Arimidex+Denosumab, NED May 2014: recurrence in right acetabulum: 15 fractions radiation Jan 2015: lesion in left cerebellum: resection & gamma knife treatment Mar 2015: major general progression; small mets confirmed in rt axilla, rt breast, T7 vertebra, possible met as isolated spiculated pulmonary nodule left lung[LIST][]27 Mar 2015: start Kadcyla, discontinue aromotase inhibitors; within two weeks axilla/rt breast lesions are shrinking noticeably[]18 April: resume letrozole []May: all lesions disappeared or dormant[]June - discontinue Kadcyla due to low platelets[*]Aug & Nov 2015 MRI brain/spinal scans all negative for CNS disease: no recurrence to date Fall 2015 - stereotactic radiation to lingering T3 lesion to relieve pain; 90% effective within weeks July 2019 - discontinued Letrozole due to side effects April 2020 - short course steretactic radiation to 2 cm lesion in upper left lung; subsequent scan finds it reduced Mar 2021 - 6.5 cm mass found in left lung; FISH finds it is PR-, ER- and strongly HER2+. 16 April 2021 - Resume Kadcyla.