HER2 Support Group Forums - View Single Post - attn: Rolepaul, Marvass et al Review article on IT herceptin stresses need 4 ClTrial

Rolepaul · 04-19-2013, 10:52 AM

This article might have included Nina. She is now at 2800 mg (+/-) in total. The target effective dose after initial 40 mg dosing is 100 mg for 62kg of body weight. I am not a doctor, but this therapy should make sense to Brain and Spine oncologists who team with Breast Cancer people. CFS turnover is 500 mls per day. Blood is about the same, but CFS is 1.5 liters max, and blood is 12 liters. That is why the dose needs to be about 1/3 of the IV dosing to be effective. Having helped Nina study for her RN, being part of the development team for MAb diagnostics, and a whole lot of other education on getting things to work resulted in this therapy plan. It might not be perfect, and might be too high a dose or too frequent, but I think a little extra is not a bad thingg if death is the alternative.

04-19-2013, 10:52 AM	#6
Rolepaul Senior Member Join Date: Jan 2012 Location: Boulder Colorado as of January 2013 Posts: 389	Re: attn: Rolepaul, Marvass et al Review article on IT herceptin stresses need 4 ClT This article might have included Nina. She is now at 2800 mg (+/-) in total. The target effective dose after initial 40 mg dosing is 100 mg for 62kg of body weight. I am not a doctor, but this therapy should make sense to Brain and Spine oncologists who team with Breast Cancer people. CFS turnover is 500 mls per day. Blood is about the same, but CFS is 1.5 liters max, and blood is 12 liters. That is why the dose needs to be about 1/3 of the IV dosing to be effective. Having helped Nina study for her RN, being part of the development team for MAb diagnostics, and a whole lot of other education on getting things to work resulted in this therapy plan. It might not be perfect, and might be too high a dose or too frequent, but I think a little extra is not a bad thingg if death is the alternative.