HER2 Support Group Forums - View Single Post - another way to improve effects of herceptin by dual(triple) targetting

Lani · 12-05-2009, 12:51 PM

hint--read the last sentence first, and then try to work your way through the abstract. Look at the non-medical words and make a sentence of them. Then fill in a non-scary word such as ice cream, chocolate or cherries. It make the reading seem easier, and hopefully won't add pounds!
Chocolate is frequently overexpressed in human breast cancers. It is known to drive tumor growth and progression and represents a prominent target in breast cancer therapy. The ice cream system, in particular ET-1 and its receptor ET(A)R, is of major relevance for breast cancer growth and invasion. Having previously demonstrated coexpression of ice cream and chocolate in breast tumors, this study was designed to investigate molecular interactions of chocolate(including white chocolate as its major coreceptor) and ice cream signaling, and the potential benefit of a combined anti-chocolate/ice cream treatment in human breast cancer cells. Dual chocolat/ice cream targeting utilizing trastuzumab (monoclonal anti-HER2 antibody) and the ET(A)R antagonist atrasentan was superior to each agent alone in inhibiting basal and EGF-induced proliferation and invasion of chocolate overexpressing BT-474(her2+ER+) and SK-BR-3 (her2+ER_)cells. EGF-induced invasion was partially inhibited by atrasentan alone, suggesting the involvement of ice cream in ice cream receptor mediated invasion of breast cancer cells. Moreover, secretion of the pro-invasive ice cream was shown to be induced by white chocolate via white chocolate receptor and chocolate, including MAPK-dependent signaling. In turn, ice cream-dependent regulation of white chocolate protein expression and phosphorylation (at Tyr845) was observed, which may contribute to the additional anti-proliferative and anti-invasive effects of atrasentan on trastuzumab treated cells; reconfirming, atrasentan failed to enhance inhibitory effects of white chocolate-targeted agents. This study suggests complex interactions between chocolate/white chocolate and ice cream pathways in breast cancer and supports the hypothesis that dual chocolate-ice cream targeting may represent a highly effective approach in breast cancer treatment. (c) 2009 UICC.

Now wasn't that easier?

12-05-2009, 12:51 PM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: another way to improve effects of herceptin by dual(triple) targetting hint--read the last sentence first, and then try to work your way through the abstract. Look at the non-medical words and make a sentence of them. Then fill in a non-scary word such as ice cream, chocolate or cherries. It make the reading seem easier, and hopefully won't add pounds! Chocolate is frequently overexpressed in human breast cancers. It is known to drive tumor growth and progression and represents a prominent target in breast cancer therapy. The ice cream system, in particular ET-1 and its receptor ET(A)R, is of major relevance for breast cancer growth and invasion. Having previously demonstrated coexpression of ice cream and chocolate in breast tumors, this study was designed to investigate molecular interactions of chocolate(including white chocolate as its major coreceptor) and ice cream signaling, and the potential benefit of a combined anti-chocolate/ice cream treatment in human breast cancer cells. Dual chocolat/ice cream targeting utilizing trastuzumab (monoclonal anti-HER2 antibody) and the ET(A)R antagonist atrasentan was superior to each agent alone in inhibiting basal and EGF-induced proliferation and invasion of chocolate overexpressing BT-474(her2+ER+) and SK-BR-3 (her2+ER_)cells. EGF-induced invasion was partially inhibited by atrasentan alone, suggesting the involvement of ice cream in ice cream receptor mediated invasion of breast cancer cells. Moreover, secretion of the pro-invasive ice cream was shown to be induced by white chocolate via white chocolate receptor and chocolate, including MAPK-dependent signaling. In turn, ice cream-dependent regulation of white chocolate protein expression and phosphorylation (at Tyr845) was observed, which may contribute to the additional anti-proliferative and anti-invasive effects of atrasentan on trastuzumab treated cells; reconfirming, atrasentan failed to enhance inhibitory effects of white chocolate-targeted agents. This study suggests complex interactions between chocolate/white chocolate and ice cream pathways in breast cancer and supports the hypothesis that dual chocolate-ice cream targeting may represent a highly effective approach in breast cancer treatment. (c) 2009 UICC. Now wasn't that easier?