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Cathya · 01-18-2019, 02:07 PM

Juls;

Ask about Ibrance/Letrozole. I know it's working very well for Lauren who is also triple positive. I can ask her to contact you if you like.

Juls, I know it is written that Ibrance is for Her2- so your onc might not necessarily think of it but I suggest you push him/her. Here's a report and part I've highlighted

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122240/

Ongoing and future palbociclib studies
As of February 2018, there were 70 ongoing breast cancer interventional studies that involve palbociclib. Select ongoing clinical trials to further assess the role of palbociclib in breast cancer are shown in Table 3. Currently, ongoing studies are evaluating the safety and efficacy of palbociclib in combination with endocrine therapy in patients with early breast cancer (adjuvant and neoadjuvant) and HER2+ metastatic breast cancer in combination with endocrine therapy, pertuzumab, and trastuzumab. Palbociclib is also being studied in patients with other tumor types, including gastrointestinal, and lung cancers.

My own oncologist said there are very positive reports coming for Her2+'s and Ibrance.

Cathy

01-18-2019, 02:07 PM	#83
Cathya Senior Member Join Date: Sep 2005 Location: Ontario, Canada Posts: 752	Re: Treatment after Kadcyla? Juls; Ask about Ibrance/Letrozole. I know it's working very well for Lauren who is also triple positive. I can ask her to contact you if you like. Juls, I know it is written that Ibrance is for Her2- so your onc might not necessarily think of it but I suggest you push him/her. Here's a report and part I've highlighted https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122240/ Ongoing and future palbociclib studies As of February 2018, there were 70 ongoing breast cancer interventional studies that involve palbociclib. Select ongoing clinical trials to further assess the role of palbociclib in breast cancer are shown in Table 3. Currently, ongoing studies are evaluating the safety and efficacy of palbociclib in combination with endocrine therapy in patients with early breast cancer (adjuvant and neoadjuvant) and HER2+ metastatic breast cancer in combination with endocrine therapy, pertuzumab, and trastuzumab. Palbociclib is also being studied in patients with other tumor types, including gastrointestinal, and lung cancers. My own oncologist said there are very positive reports coming for Her2+'s and Ibrance. Cathy __________________ Cathy Diagnosed Oct. 2004 3 cm ductal, lumpectomy Nov. 2004 Diagnosed Jan. 2005 tumor in supraclavicular node Stage 3c, Grade 3, ER/PR+, Her2++ 4 AC, 4 Taxol, Radiation, Arimidex, Actonel Herceptin for 9 months until Muga dropped and heart enlarged Restarting herceptin weekly after 4 months off Stopped herceptin after four weekly treatments....score dropped to 41 Finished 6 years Arimidex May 2015 diagnosed with ovarian cancer Stage 1C started 6 treatments of carboplatin/taxol Genetic testing show BRCA1 VUS Nice! My hair came back really curly. Hope it lasts lol. Well it didn't but I liked it so I'm now a perm lady 29 March 2018 Lung biopsy following chest CT showing tumours in pleura of left lung, waiting for results to the question bc or ovarian April 20, 2018 BC mets confirmed, ER/PR+ now Her2- Questions about the possibility of ovarian spread and mets to bones so will be tested and monitored for these. To begin new drug Palbociclib (Ibrance) along with Letrozole May, 2018. Genetic testing of ovarian tumour and this new lung met will take months. To see geneticist to be retested for BRCA this week....still BRCA VUS CA125 has declined from 359 to 12 as of Aug.23/18 Last edited by Cathya; 01-18-2019 at 02:26 PM..