HER2 Support Group Forums - View Single Post - Paradoxical actions of a c-Src inhibitor on long-term ER deprived cells

Lani · 06-25-2010, 11:46 PM

MCF-7 cells , the most commonly used breast cancer cell line in research are her2-. Occasionally you will see studies on MCF-7 cells which are an artificial construct having been transfected (infected with additional genetic material to change them) with her2

So these cells were ER+ and her2-

I have posted a list of the most common her+ cell lines used in research if you

try the search function I think you'll find it

I don't believe they studied what made these particular cells resistant to estrogen deprivation (and sensitive to estrogen causing apoptosis),but from previous work by these authors I don't believe they noted acquisition of her2 amplification as the cause of this change.

06-25-2010, 11:46 PM	#2
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: Paradoxical actions of a c-Src inhibitor on long-term ER deprived cells MCF-7 cells , the most commonly used breast cancer cell line in research are her2-. Occasionally you will see studies on MCF-7 cells which are an artificial construct having been transfected (infected with additional genetic material to change them) with her2 So these cells were ER+ and her2- I have posted a list of the most common her+ cell lines used in research if you try the search function I think you'll find it I don't believe they studied what made these particular cells resistant to estrogen deprivation (and sensitive to estrogen causing apoptosis),but from previous work by these authors I don't believe they noted acquisition of her2 amplification as the cause of this change.