HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 04-20-2007, 04:13 PM

In essence much still to know but for HER 2

Omega three - good
Omega nine - good
low Omega six - good

Clearly as usual it is not that simple but the summary below adds to the weight of evidence that strict moderation of fat intake, balancing the omega threes and sixes and quality of intake are well worth serious consideration.

As usual if undertaking significant dietary change please talk to your advisers.

http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17134970

ABSTRACT

CONCLUSIONS: i) These findings reveal that the omega-3 PUFA ALA suppresses overexpression of HER2 oncogene at the transcriptional level, which, in turn, interacts synergistically with anti-HER2 trastuzumab- based immunotherapy. ii) Our results molecularly support a recent randomized double-blind placebo-controlled clinical trial suggesting that ALA may be a potential dietary alternative or adjunct to currently used drugs in the management of HER2-positive breast carcinomas. iii) Considering our previous findings demonstrating the <<HER2 upregulatory actions>> of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the <<HER2 down-regulatory actions >> of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent <<fat features>> of the <<Mediterranean diet>>, should be extremely efficient at blocking HER2 expression in breast cancer cells.

04-20-2007, 04:13 PM	#138
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	<<Mediterranean diet>>, should be extremely efficient at blocking HER2 In essence much still to know but for HER 2 Omega three - good Omega nine - good low Omega six - good Clearly as usual it is not that simple but the summary below adds to the weight of evidence that strict moderation of fat intake, balancing the omega threes and sixes and quality of intake are well worth serious consideration. As usual if undertaking significant dietary change please talk to your advisers. http://www.ncbi.nlm.nih.gov/entrez/q..._uids=17134970 ABSTRACT CONCLUSIONS: i) These findings reveal that the omega-3 PUFA ALA suppresses overexpression of HER2 oncogene at the transcriptional level, which, in turn, interacts synergistically with anti-HER2 trastuzumab- based immunotherapy. ii) Our results molecularly support a recent randomized double-blind placebo-controlled clinical trial suggesting that ALA may be a potential dietary alternative or adjunct to currently used drugs in the management of HER2-positive breast carcinomas. iii) Considering our previous findings demonstrating the <<HER2 upregulatory actions>> of the omega-6 PUFA linolenic acid (LA; 18:2n-6) and the <<HER2 down-regulatory actions >> of the omega-3 PUFA docosahexaenoic acid (DHA; 22:6n-3) and of the omega-9 monounsaturated fatty acid oleic acid (OA; 18:1n-9), it is reasonable to suggest that a low omega-6/omega-3 PUFA ratio and elevated MUFA levels, the two prominent <<fat features>> of the <<Mediterranean diet>>, should be extremely efficient at blocking HER2 expression in breast cancer cells.