HER2 Support Group Forums - View Single Post - Coconut fat (MCTs) downregulate PPAR gamma HER2 Upregulates

R.B. · 06-14-2007, 05:11 AM

Another snippet from my wanders.

MCT (three fats in on a chemical spine that look a bit like an E) are made from mid length fats which are found in coconut (and other things).

Reports have suggested MCTs help in weight loss.

PPARs work with fats to control metabolism and fat storage and probably lots else too.

PPAR gamma seems to be downgraded by MCTs.

Increased PPAR gamma is a factor in HER2 BC.

I have not found any trials with MCTs and BC which would answer the question does increased dietary MCTs reduce the risk of HER 2 BC.

It does raise more evidence as to the possible involvements of fats in HER2 risk factors.

There is lots on the web on MCTs. They are saturated generally and so some argue against them. They are also suggested to reduce bacterial infection.

If you do think about adding them to your diet, moderation is key and please talk to your advisor.

RB

http://www.obesityresearch.org/cgi/c.../full/11/6/734

Consistent with this prediction, we found that mRNA levels for PPAR{gamma}2 were substantially reduced in the adipose tissue of MCT-fed animals (Figure 4A)

http://clincancerres.aacrjournals.or...tract/9/8/3198

HER2 Regulation of Peroxisome Proliferator-activated Receptor {gamma} (PPAR{gamma}) Expression and Sensitivity of Breast Cancer Cells to PPAR{gamma} Ligand Therapy1
Zhibo Yang, Rozita Bagheri-Yarmand, Seetharaman Balasenthil, Gabriel Hortobagyi, Aysegul A. Sahin, Christopher J. Barnes and Rakesh Kumar2

Departments of Molecular and Cellular Oncology [Z. Y., R. B-Y., S. B., C. J. B., R. K.], Breast Medical Oncology [G. H.], and Pathology [A. A. S.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030

Conversely, down-regulation of HER2 by anti-HER2 monoclonal antibody Herceptin led to a decreased level of PPAR{gamma} protein and sensitization of breast cancer cells to the inhibitory effects of troglitazone. In summary, these findings show for the first time that HER2 up-regulates PPAR{gamma} expression and modulates the sensitivity of breast cancer cells to PPAR{gamma} ligand therapy.

06-14-2007, 05:11 AM	#1
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Coconut fat (MCTs) downregulate PPAR gamma HER2 Upregulates Another snippet from my wanders. MCT (three fats in on a chemical spine that look a bit like an E) are made from mid length fats which are found in coconut (and other things). Reports have suggested MCTs help in weight loss. PPARs work with fats to control metabolism and fat storage and probably lots else too. PPAR gamma seems to be downgraded by MCTs. Increased PPAR gamma is a factor in HER2 BC. I have not found any trials with MCTs and BC which would answer the question does increased dietary MCTs reduce the risk of HER 2 BC. It does raise more evidence as to the possible involvements of fats in HER2 risk factors. There is lots on the web on MCTs. They are saturated generally and so some argue against them. They are also suggested to reduce bacterial infection. If you do think about adding them to your diet, moderation is key and please talk to your advisor. RB http://www.obesityresearch.org/cgi/c.../full/11/6/734 Consistent with this prediction, we found that mRNA levels for PPAR{gamma}2 were substantially reduced in the adipose tissue of MCT-fed animals (Figure 4A) http://clincancerres.aacrjournals.or...tract/9/8/3198 HER2 Regulation of Peroxisome Proliferator-activated Receptor {gamma} (PPAR{gamma}) Expression and Sensitivity of Breast Cancer Cells to PPAR{gamma} Ligand Therapy1 Zhibo Yang, Rozita Bagheri-Yarmand, Seetharaman Balasenthil, Gabriel Hortobagyi, Aysegul A. Sahin, Christopher J. Barnes and Rakesh Kumar2 Departments of Molecular and Cellular Oncology [Z. Y., R. B-Y., S. B., C. J. B., R. K.], Breast Medical Oncology [G. H.], and Pathology [A. A. S.], The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030 Conversely, down-regulation of HER2 by anti-HER2 monoclonal antibody Herceptin led to a decreased level of PPAR{gamma} protein and sensitization of breast cancer cells to the inhibitory effects of troglitazone. In summary, these findings show for the first time that HER2 up-regulates PPAR{gamma} expression and modulates the sensitivity of breast cancer cells to PPAR{gamma} ligand therapy.