[Adriana Mangus]

Hi Karen,

Hope all is well with you. I have been on navelbine before and worked for me. I have other options at this time, I have to wait for the CT-Scan results. I just had it done last night, March 23.

This is just the beginning for you, Karen. You have so many options to treat lung mets. Just curious did you test positive for the P53?

50% of patients do test positive for this mutation, my oncologist is well aware of it. I don't know why they don't communicate any of this to us. It bugs me!!! Are we too stupid to understand the medical lingo or what??? Argh....

I, too had the genomic studies done by Foundation One, they identified three clinical trials for me;

Genomic alteration detected

GNAS amplification - equivocal FDA approved therapy; trametibin


PIK3CA amplification FDA approved therapy;Everolimus Temsirolimus I heard serious side effects with
everolimus might occur


and.....
TP53

therapy has not been FDA approved but a potential clinical trial is taking place in Cambridge, MA. This is something I would like to enroll in, - providing at the time of enrolling my brian shows NED as the clinic does not accept patients with brain metastases, I understand most clinical trial don't because of poor prognosis. I say heck with the statistics, as long as I'm here I will try everything in my power to continue fighthing this beast- -, kevetrin is the drug that activates p53 and may be effective in treatment of drug resistant cancer with mutant p53. Phase 1 clinical trial is underway. One problem for me is the distance, I live in California. I will definitely talk with my oncologist next week about this.

Take care and please keep us posted.

Love,

Adriana