HER2 Support Group Forums - View Single Post - can eating(drinking) probiotic bacteria prevent the development of breast cancer?

Lani · 02-18-2014, 02:34 AM

OK--here is an attempt at a puppy dog version:

Recent studies suggest health benefits including protection from cancer after eating fermented foods such as probiotic yogurt, though the mechanisms are not well understood. Here we tested hypotheses having to do with the mechanism of how this may actually come about, using two different animal models: the first model studied development of breast cancer when eating a Westernized diet, and the second studied animals with a genetic tendency to get breast cancer. For the first model, Swiss mice who had not been bread to have a tendency to get breast cancer were fed a Westernized(containing lots of fats that may be harmful ie, not olive oil types, but lard types) chow (yes, chow) putting them at increased risk for development of breast tumors. In this Westernized diet model, the development of cancer in the mouse breasts was inhibited by routine exposure to Lactobacillus reuteri ATCC-PTA-6475, a kind of probiotic bacteria found in European yogurts especially in drinking water. The second model was FVB strain erbB2 (HER2) mutant mice, genetically susceptible to mammary tumors mimicking breast cancers in humans, being fed a regular (non-Westernized) chow diet. We found that supplemening the mice orally with these purified lactic acid bacteria alone was sufficient to inhibit features of breast cancer formation in both models. The protective mechanism was determined to be microbially-triggered CD4+CD25+ lymphocytes(a type of immune cell). When isolated and transplanted into other subjects, these L. reuteri(probiotic bacteria)-stimulated lymphocytes were sufficient to convey transplantable anti-cancer protection in the animals which received them. These data demonstrate that host immune responses to environmental microbes significantly impact and inhibit cancer progression in distal tissues such as breasts, even in genetically susceptible mice. This leads us to conclude that consuming fermentative microbes such as L. reuteri may offer a tractable public health approach to help counteract the accumulated dietary and genetic carcinogenic events integral in the Westernized diet and lifestyle. © 2013 Wiley Periodicals, Inc.
Copyright © 2013 UICC.
KEYWORDS:

02-18-2014, 02:34 AM	#11
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: can eating(drinking) probiotic bacteria prevent the development of breast cancer? OK--here is an attempt at a puppy dog version: Recent studies suggest health benefits including protection from cancer after eating fermented foods such as probiotic yogurt, though the mechanisms are not well understood. Here we tested hypotheses having to do with the mechanism of how this may actually come about, using two different animal models: the first model studied development of breast cancer when eating a Westernized diet, and the second studied animals with a genetic tendency to get breast cancer. For the first model, Swiss mice who had not been bread to have a tendency to get breast cancer were fed a Westernized(containing lots of fats that may be harmful ie, not olive oil types, but lard types) chow (yes, chow) putting them at increased risk for development of breast tumors. In this Westernized diet model, the development of cancer in the mouse breasts was inhibited by routine exposure to Lactobacillus reuteri ATCC-PTA-6475, a kind of probiotic bacteria found in European yogurts especially in drinking water. The second model was FVB strain erbB2 (HER2) mutant mice, genetically susceptible to mammary tumors mimicking breast cancers in humans, being fed a regular (non-Westernized) chow diet. We found that supplemening the mice orally with these purified lactic acid bacteria alone was sufficient to inhibit features of breast cancer formation in both models. The protective mechanism was determined to be microbially-triggered CD4+CD25+ lymphocytes(a type of immune cell). When isolated and transplanted into other subjects, these L. reuteri(probiotic bacteria)-stimulated lymphocytes were sufficient to convey transplantable anti-cancer protection in the animals which received them. These data demonstrate that host immune responses to environmental microbes significantly impact and inhibit cancer progression in distal tissues such as breasts, even in genetically susceptible mice. This leads us to conclude that consuming fermentative microbes such as L. reuteri may offer a tractable public health approach to help counteract the accumulated dietary and genetic carcinogenic events integral in the Westernized diet and lifestyle. © 2013 Wiley Periodicals, Inc. Copyright © 2013 UICC. KEYWORDS: