[Jackie07]

Liv,

Thought I'd posted one recent abstract that mentioned something effective in treating Triple Negagive Breast Cancer. It was an article summarizing breakthroughs in breast cancer treatment, and TNC was mentioned/included in the report.

Here's an abstract from 2010 and looks like PARP inhibitor is a good bet.


Gan To Kagaku Ryoho. 2010 Jul;37(7):1187-91.
[Breakthrough breast cancer treatment--PARP inhibitor, BRCA, and triple negative breast cancer].

[Article in Japanese]
Hashimoto K, Tamura K.
Source

Breast and Medical Oncology Division, Outpatient Clinic, National Cancer Center Hospital, Tokyo, Japan.

Abstract

PARP and BRCA are both known as DNA repair enzymes. Functional loss of BRCA cell with PARP inhibition indicates apoptosis. Triple negative breast(TNB)cancer(estrogen receptor-negative, progesterone receptor-negative, HER-2 expression negative)are well associated with basal-type breast cancer. Basal-type breast cancer often has loss of BRCA and showed poor clinical outcomes. Considering the similar molecular profiles of Basal-type breast cancer and TNB cancer, clinical trials using PARP inhibitor for patients with TNB cancer has been warranted. A randomized phase II trial comparing gemcitabine and carboplatin(GC)to GC plus BSI-201(PARP inhibitor)in patients with metastatic TNB cancer showed significantly longer progression-free survival and overall survival. We herein summarized up-to-date knowledge of PARP inhibitor in association with TNB and BRCA.