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R.B. · 08-16-2006, 02:57 AM

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum

1: J Dent Res. 2006 Jul;85(7):648-52.Click here to read Links
Omega-3 Fatty Acid effect on alveolar bone loss in rats.

* Kesavalu L,
* Vasudevan B,
* Raghu B,
* Browning E,
* Dawson D,
* Novak JM,
* Correll MC,
* Steffen MJ,
* Bhattacharya A,
* Fernandes G,
* Ebersole JL.

Center for Oral Health Research, College of Dentistry, 159 HSRB, University of Kentucky, Lexington, KY 40536-0305, USA; and.

Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (omega)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (omega-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the omega-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with omega-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an omega-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that omega-3 FA may be a useful adjunct in the treatment of periodontal disease. Abbreviations: PUFA, polyunsaturated fatty acid; EPA, eicosapentanoic acid; DHA, docosahexanoic acid; and PCR, polymerase chain-reaction.

PMID: 16798867 [PubMed - in process]

08-16-2006, 02:57 AM	#3
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	omega-3 FA may be a useful adjunct in the treatment of periodontal disease. http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_docsum 1: J Dent Res. 2006 Jul;85(7):648-52.Click here to read Links Omega-3 Fatty Acid effect on alveolar bone loss in rats. * Kesavalu L, * Vasudevan B, * Raghu B, * Browning E, * Dawson D, * Novak JM, * Correll MC, * Steffen MJ, * Bhattacharya A, * Fernandes G, * Ebersole JL. Center for Oral Health Research, College of Dentistry, 159 HSRB, University of Kentucky, Lexington, KY 40536-0305, USA; and. Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (omega)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (omega-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the omega-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with omega-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an omega-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that omega-3 FA may be a useful adjunct in the treatment of periodontal disease. Abbreviations: PUFA, polyunsaturated fatty acid; EPA, eicosapentanoic acid; DHA, docosahexanoic acid; and PCR, polymerase chain-reaction. PMID: 16798867 [PubMed - in process]