HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 08-13-2008, 02:01 PM

Another mechanism by which long chain Omega 3 blocks BC, this time through BRAC1.

1: Oncol Rep. 2007 Apr;17(4):713-9.Click here to read Links
Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids.
Jourdan ML, Mahéo K, Barascu A, Goupille C, De Latour MP, Bougnoux P, Rio PG.

INSERM, E 0211; Université François Rabelais; CHU Bretonneau, Tours, F-37000, France.

Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.

08-13-2008, 02:01 PM	#257
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Another mechanism by which long chain Omega 3 blocks BC, this time through BRAC1. 1: Oncol Rep. 2007 Apr;17(4):713-9.Click here to read Links Increased BRCA1 protein in mammary tumours of rats fed marine omega-3 fatty acids. Jourdan ML, Mahéo K, Barascu A, Goupille C, De Latour MP, Bougnoux P, Rio PG. INSERM, E 0211; Université François Rabelais; CHU Bretonneau, Tours, F-37000, France. Any factor affecting BRCA gene regulation may be of interest in the prevention of breast tumourigenesis. We studied the influence of dietary docosahexaenoic acid (DHA), a major omega-3 fatty acid present in marine products, on rat autochthonous mammary tumourigenesis. DHA-supplementation significantly reduced the incidence of tumours (30%, P=0.007) and led to a 60% increase (P=0.02) in BRCA1 protein level. Since DHA influences the product of a major tumour suppressor gene, this finding may contribute to the observation that high-fish consumption reduces the risk of breast cancer.