HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 01-01-2016, 03:02 PM

"Sugar in western diets increases risk for breast cancer tumors and metastasis"

"The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Center. "

http://medicalxpress.com/news/2016-0...st-cancer.html

What's this got to do with Omega 3 and 6 is probably your first thought.

A pathway increased by sugar is the expression of an enzyme called LOX12, which is an enzyme that is one of the key pathways by which plant based Omega 6 linoleic acid and the longer chain arachidonic acid are converted to downstream oxidized products that are highly bio-active including 12HETE, which has roles in controlling cell growth and invasion.

http://www.nature.com/bjc/journal/v1...c2011194a.html

The pathways are multiple and complex, and much remains to be determined, but several oxidized products of Omega 6s are associated with increased risks of cancer by multiple mechanisms.

So here it appears we have a cross amplification of relevant pathways by excess sugar and Omega 6s in the diet.

I see Lani has also posted the story. http://her2support.org/vbulletin/showthread.php?t=64352

This emphases how interlinked things are and that approaches need to be holistic.

01-01-2016, 03:02 PM	#429
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. "Sugar in western diets increases risk for breast cancer tumors and metastasis" "The high amounts of dietary sugar in the typical Western diet may increase the risk of breast cancer and metastasis to the lungs, according to a study at The University of Texas MD Anderson Cancer Center. " http://medicalxpress.com/news/2016-0...st-cancer.html What's this got to do with Omega 3 and 6 is probably your first thought. A pathway increased by sugar is the expression of an enzyme called LOX12, which is an enzyme that is one of the key pathways by which plant based Omega 6 linoleic acid and the longer chain arachidonic acid are converted to downstream oxidized products that are highly bio-active including 12HETE, which has roles in controlling cell growth and invasion. http://www.nature.com/bjc/journal/v1...c2011194a.html The pathways are multiple and complex, and much remains to be determined, but several oxidized products of Omega 6s are associated with increased risks of cancer by multiple mechanisms. So here it appears we have a cross amplification of relevant pathways by excess sugar and Omega 6s in the diet. I see Lani has also posted the story. http://her2support.org/vbulletin/showthread.php?t=64352 This emphases how interlinked things are and that approaches need to be holistic. Last edited by R.B.; 01-01-2016 at 03:10 PM..