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Old 10-14-2013, 12:58 AM   #3
donocco
Senior Member
 
Join Date: Oct 2013
Posts: 268
Re: A Study of PI3-Kinase Inhibitor GDC-0941

I did some basic research on the drug GDC-0941. Apparently its generic name is Pictilsib. I saw references to its possible use in a number of types of cancer such as Multiple Myeloma, Breast Cancer, various types of Lymphomas and Im sure there are others.

There was one Phase one study of GDC-0941 in the treatment of Multiple Myeloma aqnd some advanced solid tumours. There were a range of doses listed, but one metastatic myeloma patient had a partial response at 330mg GDC-041 daily. The maximum tolerated daily dose was determined to be 450mg daily.

The main side effects are nausea, vomiting, diarrhea, taste disturbances, loss of appetite, and fatigue. Hyperglycemia was seen in one patient taking 130mg daily and Diabetes is listed as a reason for exclusion in a clinical trial I saw.

Hope this info helps

Paul
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