HER2 Support Group Forums - View Single Post - Circadian Rhythm, eating schedule etc and treatment

Rich66 · 11-25-2009, 12:22 AM

Melatonin, Chronobiology & Cancer

(2003 NCI conference)

Download a copy of the program document
This video may be reviewed via NIH Webcast at:
http://videocast.nih.gov/ram/melatonin022803.ram
Please Note: In order to view the webcast, you will require RealPlayer installed on your machine. You can download the latest version of the player from the RealNetworks web site at:
http://www.realnetworks.com/info/freeplayer/

Dr. Bill Hrushesky
"Successful Cancer Therapy Development: Beating the Odds by Respecting Human Circadian Organization"
Director, Research Service Line
VA Research and Development
Columbia, South Carolina

Dr. David Blask
"Melatonin: An Integrative Chronobiotic Anticancer Therapy Whose Time Has Come"
Bassett Research Institute
Cooperstown, NY

Dr. Paolo Lissoni
"Clinical Experience with Melatonin Alone or Combined with the Standard Anticancer Therapies in Medical Oncology"
Division of Radiation Oncology, San Gerardo Hospital
Milan, Italy

other NCI meeting links:
http://www3.cancer.gov/occam/conferences.html

crude notes on the video:

Hrushesky
Founded Medical Chronotherapeutics

Circadian rhythm can be tracked via wristband

Rise in rate and BP before rising as indicator of circadian rhythm

There is a universal pain cycle, presumed circadian

Radiation is targeted to G2 part of cell cycle, most prominent in afternoon

Ovarian trial found best schedule of Dox in morning, Cisplatinum in evening
5 yr 44% survival in optimal schedule vs 11% when timing was reversed

Colorectal cancer trial
Circadian oriented delivery of 5FU (S phase agent) in evening/overnight best, allows increased dose.

Renal cancer treatment greatly optimized by circadian delivery

Hepatic arterial efficacy increased with chronotherapy

Lissoni

02:28:32 melatonin for neuron dosages w/Il-2 , it produces Il-12

Other pineal gland hormones help too and are amplified by melatonin 02:35:00

Naltrexone beneficial

Low dose Il-2 helpful

IL-12 + Il-2 melatonin and total pineal replacement therapy 02:37:00

Objective response not everything, immune response contributes to overall survival

02:38:50
Rationale of melatonin-chemotherapy association in cancer

Increased efficacy
Prevention of lymphocyte damage, potebtial increased survival
Antioxidant induced increased cytotoxic activity of chemo and possible enhanced tumor rate

Prevention of toxicity
Thrombocytopenia, neurotoxicity, immunosuppression-related symptoms, asthenia

02:40:23
Melatonin increased efficacy amongst many chemos and cancers, taxol, gemcitabine etc
02:43:57
Rationale of melatonin-classical endocrine therapy
MLT stimulates endocrine receptor expression
Melatonin may inhibit tumor growth factor production
May reverse endocrine resistance
May have direct cytostatic action
Melatonin may modulate the expression of oncogenes and antioncogenes involved in regulating cancer cell hormone dependency

02:44:28 combined LHRH+ MLT therapy for metastatic prostate cancer

02:44:50 MBC results, Tamoxifen + 20mg melatonin

02:45:58 Tam + melatonin in non hormonal cancers

Future perspectives
MLT receptors
Other pineal hormones

Q&A

02:50:38
Q: type of light important?
Blaska: type of light at night very important to MLT suppression. Low light not so much.
Blue green most potent for suppression,low level red light ok, duration length important
Length of day extremes can effect

H: Doxo/Cis variation of circadian relationship seasonal. Incidence of cancer seasonal
Eg cervical peak seasonal and inverted phase in latitudes
Sexuality seasonality may influence, urbanization artificial lights, lack of light

Blaska: rodents nocturnal, humans diurnal. But both have nocturnal melatonin surge. (i.e. mouse circadian studies relevant) Artificial light during day much dimmer, night light brighter..modern life environment works against/reverses normal circadian tuning.>>

Q: depression and light

H: Tuning circadian response: : Darkness at night. MLT at night. bright light in morning, early exercise for early bed

Q: treatment
L: disease as well as chemo disrupts melatonin. Melatonin monitoring could be helpful biomarker

H: Beta blockers and other drugs inhibit melatonin

B: aging, then drugs, tv etc increase cancer in aging

H: aging might be tuned by tuning..healthy lifestyle

H: chronotherapy in dish dismissed in 70’s, focus became ablating rhythms instead of tapping into them

H: Melatonin peaks at puberty. By 40, very weak and then worse. Aging depression and cancer might be modulated by mlt

B: exercise and diet can effect nocturnal amount of mlt

Expanded/dedicated Melatonin thread: http://her2support.org/vbulletin/sho...580#post213580

11-25-2009, 12:22 AM	#9
Rich66 Senior Member Join Date: Feb 2008 Location: South East Wisconsin Posts: 3,431	Re: Circadian Rhythm, eating schedule etc and treatment Melatonin, Chronobiology & Cancer (2003 NCI conference) Download a copy of the program document This video may be reviewed via NIH Webcast at: http://videocast.nih.gov/ram/melatonin022803.ram Please Note: In order to view the webcast, you will require RealPlayer installed on your machine. You can download the latest version of the player from the RealNetworks web site at: http://www.realnetworks.com/info/freeplayer/ Dr. Bill Hrushesky "Successful Cancer Therapy Development: Beating the Odds by Respecting Human Circadian Organization" Director, Research Service Line VA Research and Development Columbia, South Carolina Dr. David Blask "Melatonin: An Integrative Chronobiotic Anticancer Therapy Whose Time Has Come" Bassett Research Institute Cooperstown, NY Dr. Paolo Lissoni "Clinical Experience with Melatonin Alone or Combined with the Standard Anticancer Therapies in Medical Oncology" Division of Radiation Oncology, San Gerardo Hospital Milan, Italy other NCI meeting links: http://www3.cancer.gov/occam/conferences.html crude notes on the video: Hrushesky Founded Medical Chronotherapeutics Circadian rhythm can be tracked via wristband Rise in rate and BP before rising as indicator of circadian rhythm There is a universal pain cycle, presumed circadian Radiation is targeted to G2 part of cell cycle, most prominent in afternoon Ovarian trial found best schedule of Dox in morning, Cisplatinum in evening 5 yr 44% survival in optimal schedule vs 11% when timing was reversed Colorectal cancer trial Circadian oriented delivery of 5FU (S phase agent) in evening/overnight best, allows increased dose. Renal cancer treatment greatly optimized by circadian delivery Hepatic arterial efficacy increased with chronotherapy Lissoni 02:28:32 melatonin for neuron dosages w/Il-2 , it produces Il-12 Other pineal gland hormones help too and are amplified by melatonin 02:35:00 Naltrexone beneficial Low dose Il-2 helpful IL-12 + Il-2 melatonin and total pineal replacement therapy 02:37:00 Objective response not everything, immune response contributes to overall survival 02:38:50 Rationale of melatonin-chemotherapy association in cancer Increased efficacy Prevention of lymphocyte damage, potebtial increased survival Antioxidant induced increased cytotoxic activity of chemo and possible enhanced tumor rate Prevention of toxicity Thrombocytopenia, neurotoxicity, immunosuppression-related symptoms, asthenia 02:40:23 Melatonin increased efficacy amongst many chemos and cancers, taxol, gemcitabine etc 02:43:57 Rationale of melatonin-classical endocrine therapy MLT stimulates endocrine receptor expression Melatonin may inhibit tumor growth factor production May reverse endocrine resistance May have direct cytostatic action Melatonin may modulate the expression of oncogenes and antioncogenes involved in regulating cancer cell hormone dependency 02:44:28 combined LHRH+ MLT therapy for metastatic prostate cancer 02:44:50 MBC results, Tamoxifen + 20mg melatonin 02:45:58 Tam + melatonin in non hormonal cancers Future perspectives MLT receptors Other pineal hormones Q&A 02:50:38 Q: type of light important? Blaska: type of light at night very important to MLT suppression. Low light not so much. Blue green most potent for suppression,low level red light ok, duration length important Length of day extremes can effect H: Doxo/Cis variation of circadian relationship seasonal. Incidence of cancer seasonal Eg cervical peak seasonal and inverted phase in latitudes Sexuality seasonality may influence, urbanization artificial lights, lack of light Blaska: rodents nocturnal, humans diurnal. But both have nocturnal melatonin surge. (i.e. mouse circadian studies relevant) Artificial light during day much dimmer, night light brighter..modern life environment works against/reverses normal circadian tuning.>> Q: depression and light H: Tuning circadian response: : Darkness at night. MLT at night. bright light in morning, early exercise for early bed Q: treatment L: disease as well as chemo disrupts melatonin. Melatonin monitoring could be helpful biomarker H: Beta blockers and other drugs inhibit melatonin B: aging, then drugs, tv etc increase cancer in aging H: aging might be tuned by tuning..healthy lifestyle H: chronotherapy in dish dismissed in 70’s, focus became ablating rhythms instead of tapping into them H: Melatonin peaks at puberty. By 40, very weak and then worse. Aging depression and cancer might be modulated by mlt B: exercise and diet can effect nocturnal amount of mlt Expanded/dedicated Melatonin thread: http://her2support.org/vbulletin/sho...580#post213580