['lizbeth]

Redwolf,

I did notice the I-SPY trial is based on Adriamycin, which is different than the TCH that your doctor had discussed with you.

I'm not a fan of AC-TH so I took the TOP2A genetic test back when reports popped up about using this test to see if Adriamycin would be effective. I opted for Taxotere and Herceptin. If I could redo it, I'd probably want Abraxane and Taxotere. I hated losing my hair with Taxotere. My oncologist opted for Taxotere over Paclitaxol as it gave her sister terrible neuropathy when she received treatment. I am a Less is More when it comes to chemotherapy. So it you are one of the Hit it Hard group on the board I won't be offended at all with a different opinion, lol.

I agree with Sandra that the best treatments are in clinical trials, the cutting edge. And from the Phase I there is alot of valuable information coming from the I-SPY study. Based on Phase I there already have a pretty good picture of how your cancer will react.

There are other opinions out there, so I hope the other ladies will pipe up.

Let us know what you decide.