HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 07-03-2006, 03:55 AM

Mr Menendez and Ruth Lupu are frequent authors on the subjects of fats and BC and have a particular expertise in the field.

This seems to be saying that the gene involved in the synthesis of fats by the body is key to aggressive cancers, and is suggesting that there should be a recognition that it relates to the body's metabolism (of which diet is an important factor in this case fats by implication of the FAS pathways my interpretation based on their previous studies).

Not the easiest to read but for me a "public" statement of some significance suggesting implicitly that fats and body "metabolism" have a significant role in aggressive cancers.

RB

http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum

1: Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):346-357.Click here to read Links

Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells.

* Menendez JA,
* Lupu R.

aFoundation of the Recerca Bio-Medical Institute of Girona Dr Josep Trueta, University Hospital of Girona, Dr Josep Trueta, Girona, Catalonia, Spain bDepartment of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, USA cNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA dRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA.

PURPOSE OF REVIEW: This review documents our rapidly changing perspectives on the function of fatty acid synthase-catalyzed endogenous fatty acid biogenesis in cancer biology. RECENT FINDINGS: Up-regulation of fatty acid synthase gene expression and fatty acid synthase biosynthetic activity are molecular events accompanying the pathogenesis and natural history of cancer disease. First, the increased fatty acid synthase gene expression in precursor, preinvasive and invasive cancer lesions appears to represent an indirect, early epiphenomenon, occurring in response to a microenvironment containing regions of poor oxygenation and high acidity due to, for example, lack of an adequate angiogenesis and/or nutritional supply. Second, aberrant transduction cascades driven by cancer-associated oncogenic changes subvert the downregulatory effects of circulating fatty acids. Third, fatty acid synthase-dependent endogenous fatty acid metabolism actively contributes to cancer evolution by specifically regulating the expression, activity and/or cellular localization of proteins closely related to malignant transformation and/or cancer progression. SUMMARY: Fatty acid synthase-catalyzed endogenous fatty acid metabolism appears to be an obligatory acquisition selecting a biologically aggressive sub-group of cancer cells capable of growth and survival upon stresses such as hypoxia, low pH and/or nutritional deprivation. Considering that an ever-growing body of evidence demonstrates that fatty acid synthase-driven signalling actively regulates key cancer-controlling networks, we may hereafter redefine fatty acid synthase as a metabolic oncogene in human cancer cells.

PMID: 16778562 [PubMed - as supplied by publisher]

07-03-2006, 03:55 AM	#27
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Fatty acid synthase an important factor in aggressive cancers Mr Menendez and Ruth Lupu are frequent authors on the subjects of fats and BC and have a particular expertise in the field. This seems to be saying that the gene involved in the synthesis of fats by the body is key to aggressive cancers, and is suggesting that there should be a recognition that it relates to the body's metabolism (of which diet is an important factor in this case fats by implication of the FAS pathways my interpretation based on their previous studies). Not the easiest to read but for me a "public" statement of some significance suggesting implicitly that fats and body "metabolism" have a significant role in aggressive cancers. RB http://www.ncbi.nlm.nih.gov/entrez/q...=pubmed_DocSum 1: Curr Opin Clin Nutr Metab Care. 2006 Jul;9(4):346-357.Click here to read Links Oncogenic properties of the endogenous fatty acid metabolism: molecular pathology of fatty acid synthase in cancer cells. * Menendez JA, * Lupu R. aFoundation of the Recerca Bio-Medical Institute of Girona Dr Josep Trueta, University Hospital of Girona, Dr Josep Trueta, Girona, Catalonia, Spain bDepartment of Medicine, Evanston Northwestern Healthcare Research Institute, Evanston, Illinois, USA cNorthwestern University Feinberg School of Medicine, Chicago, Illinois, USA dRobert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois, USA. PURPOSE OF REVIEW: This review documents our rapidly changing perspectives on the function of fatty acid synthase-catalyzed endogenous fatty acid biogenesis in cancer biology. RECENT FINDINGS: Up-regulation of fatty acid synthase gene expression and fatty acid synthase biosynthetic activity are molecular events accompanying the pathogenesis and natural history of cancer disease. First, the increased fatty acid synthase gene expression in precursor, preinvasive and invasive cancer lesions appears to represent an indirect, early epiphenomenon, occurring in response to a microenvironment containing regions of poor oxygenation and high acidity due to, for example, lack of an adequate angiogenesis and/or nutritional supply. Second, aberrant transduction cascades driven by cancer-associated oncogenic changes subvert the downregulatory effects of circulating fatty acids. Third, fatty acid synthase-dependent endogenous fatty acid metabolism actively contributes to cancer evolution by specifically regulating the expression, activity and/or cellular localization of proteins closely related to malignant transformation and/or cancer progression. SUMMARY: Fatty acid synthase-catalyzed endogenous fatty acid metabolism appears to be an obligatory acquisition selecting a biologically aggressive sub-group of cancer cells capable of growth and survival upon stresses such as hypoxia, low pH and/or nutritional deprivation. Considering that an ever-growing body of evidence demonstrates that fatty acid synthase-driven signalling actively regulates key cancer-controlling networks, we may hereafter redefine fatty acid synthase as a metabolic oncogene in human cancer cells. PMID: 16778562 [PubMed - as supplied by publisher] Last edited by R.B.; 10-24-2008 at 02:49 PM..