HER2 Support Group Forums - View Single Post - Topoisomerase-IIa as a Predictor of Anthracycline Response

AlaskaAngel · 10-26-2008, 03:20 PM

Deb,

By saying that, is Slamon (and are you) also saying that the exact same HER2 positive persons who might be resistant to Herceptin never benefit from Adriamycin more than they do T & C, even if they are TOPO IIA?

I'm no fan of Adriamycin -- but just trying to figure out if he is saying that those HER2s who are TOPO IIA and fail on Herceptin would not ever benefit more from Adriamycin (because the T and C alone work better (?) or as well (?) for those who fail on Herceptin than Adriamycin, even though they are TOPO IIA?)

Thanks,

AlaskaAngel

10-26-2008, 03:20 PM	#4
AlaskaAngel Senior Member Join Date: Sep 2005 Location: Alaska Posts: 2,018	Not sure I understand Deb, By saying that, is Slamon (and are you) also saying that the exact same HER2 positive persons who might be resistant to Herceptin never benefit from Adriamycin more than they do T & C, even if they are TOPO IIA? I'm no fan of Adriamycin -- but just trying to figure out if he is saying that those HER2s who are TOPO IIA and fail on Herceptin would not ever benefit more from Adriamycin (because the T and C alone work better (?) or as well (?) for those who fail on Herceptin than Adriamycin, even though they are TOPO IIA?) Thanks, AlaskaAngel