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Re: Neratinib Clinical Trial
Savta,
I wish you luck with the Neratinib trial. I was in a phase II study of lapatinib (Tykerb) for early stage breast cancer at Mayo clinic. I took the lapatinib along with the Herceptin for a year. From what I have been able to determine it is a "first cousin " of Neratinib and has similar side effects; diarrhea, some problems involving the toes and fingers, etc. I found that if I ate a low fiber diet and stayed away from milk products, I could control the diarrhea somewhat. I still had to take Imodium and Lomotil along. However, it wasn't anything I could not live with. For the first 12 weeks I also had Taxol which I think contributed to some of my problems. Good luck to you! I am very glad I had the lapatinib. I hope you get some side effects~ that should mean you are getting the real drug!
Sandra
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Diagnosed: 7/25/08 ~ age 63, no family history
Surgery: 8/14/08 Bilateral mastectomy; tumor left breast, node dissection; right prophylactic with expanders: 1/12/10 latisimuss dorsi flap on left side: 9/22/10 implants in
Pathology Report: ER/PR-; HER2+ (3+); Grade 3, StageIII; 3cm tumor plus 21/21 lymph nodes positive; 5cm DCIS
Chemo: A/C; Taxol/Herceptin/Tykerb; phase II study at Mayo adding Tykerb for early stage
Radiation: 25 rads
Vaccine: Walter Reed GP2/AE37 vaccine study ~ last booster 9/17/2012
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