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Lani · 12-07-2006, 10:57 AM

+/- 1.7 for the 67 women with no family history. Of the 27 women with a family history of breast cancer, 13 had a first-degree relative (mother or sister) with the disease. The remaining 14 women had other relatives (grandmothers, aunts, cousins, or a niece) with breast cancer. The results of multiple linear regression analysis, with HER2 as the dependent variable, showed that family history of breast cancer was significantly associated with elevated HER2 levels in the tumors (p = 0.0038), after controlling for the effects of age, tumor estrogen receptor, and DNA index. CONCLUSIONS: The association of family history of breast cancer and elevated tumor HER2 protein suggests that postmenopausal familial breast cancer may be associated with altered HER2 expression.

This is in contrast to BRCA 1/2 breast cancer which is a premenopausal disease on the whole.

Could everyone with one or more relative (mother, daughter, sister, grandmother, aunt, etc) please post how many relatives you have with breast cancer and, as best you know, what age they were (at least what decade they were in, or pre or post menopausal)when they got it, how they are/were related to you, whether they are living or dead, whether they died of the disease (or something else), how they were treated (eg. whether surgery, whether radiation therapy, whether chemo, whether antihormonals, whether oophorectomy--ovary removal--, whether herceptin), if they were her2 tested (and as best as you can find out what the results were and whether by IHC or FISH), and, if they died, how long it was between diagnosis and death (as well as whether they were diagnosed with or without metastases and their staging(TNM) if known. T stands for size of tumor and gets a 4 if they were diagnosed with metastases, N is the number of positive lymph nodes, and M is the number of distal mets. Also if you or they were ER+ and/or PR+

This does not seem to be a sexy area for the medical researchers, but I would guess, is a concern for each and every one of you.

Will try to start a roll-call, as I am certain this board holds a treasure-trove of information which might spark the interest of some researcher to settle this question more definitively.

12-07-2006, 10:57 AM	#13
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	familial her2+ breast cancer?continued +/- 1.7 for the 67 women with no family history. Of the 27 women with a family history of breast cancer, 13 had a first-degree relative (mother or sister) with the disease. The remaining 14 women had other relatives (grandmothers, aunts, cousins, or a niece) with breast cancer. The results of multiple linear regression analysis, with HER2 as the dependent variable, showed that family history of breast cancer was significantly associated with elevated HER2 levels in the tumors (p = 0.0038), after controlling for the effects of age, tumor estrogen receptor, and DNA index. CONCLUSIONS: The association of family history of breast cancer and elevated tumor HER2 protein suggests that postmenopausal familial breast cancer may be associated with altered HER2 expression. This is in contrast to BRCA 1/2 breast cancer which is a premenopausal disease on the whole. Could everyone with one or more relative (mother, daughter, sister, grandmother, aunt, etc) please post how many relatives you have with breast cancer and, as best you know, what age they were (at least what decade they were in, or pre or post menopausal)when they got it, how they are/were related to you, whether they are living or dead, whether they died of the disease (or something else), how they were treated (eg. whether surgery, whether radiation therapy, whether chemo, whether antihormonals, whether oophorectomy--ovary removal--, whether herceptin), if they were her2 tested (and as best as you can find out what the results were and whether by IHC or FISH), and, if they died, how long it was between diagnosis and death (as well as whether they were diagnosed with or without metastases and their staging(TNM) if known. T stands for size of tumor and gets a 4 if they were diagnosed with metastases, N is the number of positive lymph nodes, and M is the number of distal mets. Also if you or they were ER+ and/or PR+ This does not seem to be a sexy area for the medical researchers, but I would guess, is a concern for each and every one of you. Will try to start a roll-call, as I am certain this board holds a treasure-trove of information which might spark the interest of some researcher to settle this question more definitively.