HER2 Support Group Forums - View Single Post - TDM-1 side effects

phil · 11-04-2012, 07:53 AM

I have heard of lung mets being knocked out by t dm-1. I didn't mean to sound flippant when i said " Ind results may vary " above, of course we allwant NED. But each response is different, Lorraines took awhile , a yr to get to NED. I think they will find subgroups w/in her2 that respond more strongly to certain chemos, t dm-1 for one. and pert. Look at darlene gants amazing response to pert alone . Another factor may be prior aggr. tx to keep cancer as contained as possible, never giving it abreak , so t dm-1 has smaller target. just want appr for t dm-1 , and full appr for pert , so they can be combined , flex tx schedule , dose , etc. A few pts have stopped t dm-1 and still seem to have a+ after -effect, w/ other combos like herc/tykerb or herc /nav maintaining gains t dm-1 started. maybe pert will also help.
By the way, " blub " in diet recommendations above means fresh blueberries.

11-04-2012, 07:53 AM	#68
phil Senior Member Join Date: Nov 2010 Posts: 393	Re: TDM-1 side effects I have heard of lung mets being knocked out by t dm-1. I didn't mean to sound flippant when i said " Ind results may vary " above, of course we allwant NED. But each response is different, Lorraines took awhile , a yr to get to NED. I think they will find subgroups w/in her2 that respond more strongly to certain chemos, t dm-1 for one. and pert. Look at darlene gants amazing response to pert alone . Another factor may be prior aggr. tx to keep cancer as contained as possible, never giving it abreak , so t dm-1 has smaller target. just want appr for t dm-1 , and full appr for pert , so they can be combined , flex tx schedule , dose , etc. A few pts have stopped t dm-1 and still seem to have a+ after -effect, w/ other combos like herc/tykerb or herc /nav maintaining gains t dm-1 started. maybe pert will also help. By the way, " blub " in diet recommendations above means fresh blueberries.