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I hated Benadryl and decadron. They made my heart race. Then I would have the hangover feeling. I only had to do premeds with T & H. Once on Herceptin only, no premeds. 30 minutes and I'm out of there. Drive home and live life. I have some of the other side effects, crappy nails, etc. If your office has a phone-in nurse triage line, call in and state you are considering discontinuing Herceptin unless they cut back on Benadryl, they may be more receptive. Wait and see what they tell you when they call back. During taxol, they wouldn't cut back on the dosage but the nurses dripped it very slow once I complained. If you are scheduled to see the onc tell him how miserable the benadryl makes you feel. I guess your onc is worried about you having a reaction. As so many of us are doing it w/o premeds, it can be done. Good luck, BB
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