HER2 Support Group Forums - View Single Post - Omega 3 comparable in effect to RT on breast cancer Trial result

11-16-2005, 08:39 PM

Breast cancer and human breast cancer "cell lines" injected into mice come in "several different flavors" which behave differently!

MDA MB231 IS AN ESTROGEN NEGATIVE BREAST CANCER CELL LINE

I DO NOT believe IT IS HER2 NEU POSITIVE (just reviewed four pages of entries resulting from Google search)unless it is listed as MDA MB231H2 which stands for a MDA MB231 human breast cancer cell line which has been trasfected with genes specific to her2neu

When reviewing articles look for the cell type of human breast cancer inserted in the mice fat pad--there appear to be at least five subtypes of breast cancer distinguished by their molecular signature and comparing results in mice models of one does not imply similar results would occur with another type. Also remember mice nutrition and metabolism is different than humans'--otherwise we would eat and thrive on the same diet as they do!

11-16-2005, 08:39 PM	#2
Lani Guest Posts: n/a	Careful when reviewing articles Breast cancer and human breast cancer "cell lines" injected into mice come in "several different flavors" which behave differently! MDA MB231 IS AN ESTROGEN NEGATIVE BREAST CANCER CELL LINE I DO NOT believe IT IS HER2 NEU POSITIVE (just reviewed four pages of entries resulting from Google search)unless it is listed as MDA MB231H2 which stands for a MDA MB231 human breast cancer cell line which has been trasfected with genes specific to her2neu When reviewing articles look for the cell type of human breast cancer inserted in the mice fat pad--there appear to be at least five subtypes of breast cancer distinguished by their molecular signature and comparing results in mice models of one does not imply similar results would occur with another type. Also remember mice nutrition and metabolism is different than humans'--otherwise we would eat and thrive on the same diet as they do!