[laura4252]

I am on cycle 4 of tdm1 after three years on herceptin, three months of navelbine in 2012, then 5 months of gemzar (hated both, but tolerate herceptin well). I have lung mets, and two large tumors in my right breast (declined mastectomy, had lumpectomy and radiation in 2005, stage 0, dcis, her2+++, er/pr negative, mets to lungs in 2011). Tumors in breast are 2/3 smaller, liver enzymes are up a bit, and PET due in May. Main side effect is fatigue- I'm used to feeling endless energy, though slowing down a bit (just turned 61). Have a low tolerance for discomfort....Overall, I'm having spectacular positive results from tdm1. Hope this helps some of you out there.