HER2 Support Group Forums - View Single Post - Major study of 2000 tumors divides breast cancer into 10 diseases

Lani · 04-20-2012, 12:34 AM

the new BRCA info is entirely separate info--but may someday serve to separate her2+s (and triple negatives) into those that are more and less aggressive based on whether two genes are amplified/overexpressed or just one

the genes and pathways of 2000s tumors were examined and her2+ breast cancers whether ER+ or ER- had more in common with each other than they did with any other types of breast cancer and...if perception was not given adjuvantly...had the worse prognosis of all 10 types if I read the graph correctly

p53 is just another gene, in this case a tumor suppressor gene, which can be mutated in breast cancer. This study looked at genes and copy numbers as well as pathways (including immune gene pathways)

If you try to read scientific papers by substituting words like chocolate and ice cream for p53 or BRCA they are a lot easier to get through!!!

04-20-2012, 12:34 AM	#7
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	Re: Major study of 2000 tumors divides breast cancer into 10 diseases the new BRCA info is entirely separate info--but may someday serve to separate her2+s (and triple negatives) into those that are more and less aggressive based on whether two genes are amplified/overexpressed or just one the genes and pathways of 2000s tumors were examined and her2+ breast cancers whether ER+ or ER- had more in common with each other than they did with any other types of breast cancer and...if perception was not given adjuvantly...had the worse prognosis of all 10 types if I read the graph correctly p53 is just another gene, in this case a tumor suppressor gene, which can be mutated in breast cancer. This study looked at genes and copy numbers as well as pathways (including immune gene pathways) If you try to read scientific papers by substituting words like chocolate and ice cream for p53 or BRCA they are a lot easier to get through!!!