HER2 Support Group Forums - View Single Post - The traditional diet of Greece and cancer.

R.B. · 09-27-2013, 03:19 PM

This trial was mentioned in the paper above and is specifically relevant to HER2. I do not recall posting it before.

Essentially more of the same . . .

LA = linoleic acid the omega 6 found in quantity in most vegetable oils

Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells

http://annonc.oxfordjournals.org/con...5/11/1719.long

"This report shows, to the best of our knowledge for the first time, that dietary FAs previously characterized for either their breast cancer protective effect (ALA, EPA, DHA and OA) or its tumoricidal actions (GLA) significantly downregulate Her-2/neu ECD concentration and, consequently, the activation status of Her-2/neu in SK-Br3 and BT-474 human breast cancer cell lines, which contain Her-2/neu oncogene amplification. Remarkably, LA, a ω-6 FA with a strong tumorigenesis stimulating effect, significantly increased Her-2/neu ECD concentration. "

"Nonetheless, it is reasonable to suggest that some types of dietary FAs not only represent promising therapies for prevention and/or management of Her-2/neu-overexpressing breast carcinomas, but also may be even more beneficial when given in combination with novel therapies directed against Her-2/neu. We are currently investigating whether these findings will be helpful in the design of novel approaches to delay or prevent trastuzumab (Herceptin™) resistance. "

09-27-2013, 03:19 PM	#412
R.B. Senior Member Join Date: Mar 2006 Posts: 1,843	Re: The traditional diet of Greece and cancer. This trial was mentioned in the paper above and is specifically relevant to HER2. I do not recall posting it before. Essentially more of the same . . . LA = linoleic acid the omega 6 found in quantity in most vegetable oils Dietary fatty acids regulate the activation status of Her-2/neu (c-erbB-2) oncogene in breast cancer cells http://annonc.oxfordjournals.org/con...5/11/1719.long "This report shows, to the best of our knowledge for the first time, that dietary FAs previously characterized for either their breast cancer protective effect (ALA, EPA, DHA and OA) or its tumoricidal actions (GLA) significantly downregulate Her-2/neu ECD concentration and, consequently, the activation status of Her-2/neu in SK-Br3 and BT-474 human breast cancer cell lines, which contain Her-2/neu oncogene amplification. Remarkably, LA, a ω-6 FA with a strong tumorigenesis stimulating effect, significantly increased Her-2/neu ECD concentration. " "Nonetheless, it is reasonable to suggest that some types of dietary FAs not only represent promising therapies for prevention and/or management of Her-2/neu-overexpressing breast carcinomas, but also may be even more beneficial when given in combination with novel therapies directed against Her-2/neu. We are currently investigating whether these findings will be helpful in the design of novel approaches to delay or prevent trastuzumab (Herceptin™) resistance. "