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Hi Brenda,
I'm not sure what is meant by the cutaneous toxicity being a reflection of Erb1 inhibition as opposed to Erb2. I have still got a rash (quite pronounced) after reaching what I regard as my maximum dosage of Tykerb (4 and a half tabs [1125mg]) 7 weeks ago. What does it all mean???
Cheers, Roz
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diagnosed June 03. Rt sided Inflammatory BC in rt lower quadrant. 7cm tumour. Also 3 DCIS. 3 rounds of EC, mastectomy with axillary clearance (12 nodes+ of 19). 1 more EC. 5 weeks of rads, with weekly booster to attack skin lymph involvement. 4 cycles of Taxol. Tamoxifen.Recurrence December 04, Herceptin started early Jan05,+ Arimidex.
NED 26 mths. Recurrence early Mar07. Taxol added to Herceptin. NED. Will have total of 6 cycles, then Aromisan and Herceptin. Early Oct 07, recurrence to the pesky right upper lobe, with some pleural thickening upper rt hemithorax. T/X now the treatment. May 2008, Taxatere and Herceptin for lung recurrence
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