HER2 Support Group Forums - View Single Post - Gene Profiling Predicts Resistance To Breast Cancer Drug Herceptin

RhondaH · 02-20-2007, 10:16 AM

http://www.medicalnewstoday.com/medi...p?newsid=63485

The below is a copy paste from Wikipedia...INTERESTING:

"Inhibitors of IGF-1R
Due to the similarity of the structures of IGF-1R and the insulin receptor, especially in the regions of the ATP binding site and tyrosine kinase regions, synthesising selective inhibitors of IGF-1R is difficult. Prominent in current research are two main classes of inhibitor: 1) Tyrphostins such as AG538 and AG1024. These are in early pre-clinical testing. They are not thought to be ATP-competitive, although they are when used in EGFR as described in QSAR studies. These show some selectivity towards IGF-1R over IR. 2) Pyrrolo[2,3-d]-pyrimidine derivatives such as NVP-AEW541, which show far greater (100 fold) selectivity towards IFG-1R over IR."

Rhonda

02-20-2007, 10:16 AM	#1
RhondaH Senior Member Join Date: Sep 2005 Location: Grand Rapids, MI Posts: 1,516	Gene Profiling Predicts Resistance To Breast Cancer Drug Herceptin http://www.medicalnewstoday.com/medi...p?newsid=63485 The below is a copy paste from Wikipedia...INTERESTING: "Inhibitors of IGF-1R Due to the similarity of the structures of IGF-1R and the insulin receptor, especially in the regions of the ATP binding site and tyrosine kinase regions, synthesising selective inhibitors of IGF-1R is difficult. Prominent in current research are two main classes of inhibitor: 1) Tyrphostins such as AG538 and AG1024. These are in early pre-clinical testing. They are not thought to be ATP-competitive, although they are when used in EGFR as described in QSAR studies. These show some selectivity towards IGF-1R over IR. 2) Pyrrolo[2,3-d]-pyrimidine derivatives such as NVP-AEW541, which show far greater (100 fold) selectivity towards IFG-1R over IR." Rhonda __________________ Rhonda Dx 2/1/05, Stage 1, 0 nodes, Grade 3, ER/PR-, HER2+ (3.16 Fish) 2/7/05, Partial Mastectomy 5/18/05 Finished 6 rounds of dose dense TEC (Taxotere, Epirubicin and Cytoxan) 8/1/05 Finished 33 rads 8/18/05 Started Herceptin, every 3 weeks for a year (last one 8/10/06) 2/1/13...8 year Cancerversary and I am "perfect" (at least where cancer is concerned;) " And in the end, it's not the years in your life that count. It's the life in your years."- Abraham Lincoln