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Old 07-13-2017, 07:14 PM   #11
margo
Senior Member
 
Join Date: Sep 2005
Location: Maryland
Posts: 30
Re: What’s the next step once Perjeta/Herceptin and T-DM1 stop working?

I have been on Kadcyla (T-DM1) since February 3, 2016. It is beginning to fail. Is anyone enrolled in any of the Abemaciclib (LY2835219) trials?

http://www.lillyoncologypipeline.com/cancer-type/breast-cancer

"Significance

Despite successful HER2-directed therapies, many patients with HER2-positive breast cancer will succumb to their disease once tumor cells develop resistance. Here, we show that the cyclin D1-CDK4 pathway can mediate this resistance, and that targeting resistant tumor cells with a CDK4/6 inhibitor resensitizes them to anti-HER2 therapy by increasing their dependence on EGFR family kinase signaling. Concomitant HER2 and CDK4/6 inhibition synergistically inhibits cell proliferation,
controls tumor growth in vivo, and delays tumor recurrence in a transgenic mouse model. These effects are associated with a reduction in the phosphorylation of both Rb and S6RP, two important mediators of the G1/S transition. Our results have led to the development of a randomized clinical trial for patients with metastatic HER2-positive breast cancer."





__________________
Margo

Diagnosed 08/2004 @ 45; Metaplastic Breast Cancer (MpBC)
Stage IV, HER2 3+, ER-/PR-, Met to Liver

08/2004 - Neo-adjuvant Taxotere/Carboplatin/Herceptin (TCH) - 4 rounds.
09/2004 -
Herceptin - Weekly.
11/2004 - Liver RFA, followed w/TCH - 2 rounds.
12/2004 - Lumpectomy, axillary node dissection, followed w/TCH - 2 rounds.
05/2005 - Radiation - Breast, shoulder, neck (left side) - 35X
09/2005 - Developed severe osteoporosis - Boniva - monthly
04/2008 - Herceptin - Every 3 weeks (changed from weekly).
05/2012 - Mets: 3 new liver and 2 lymph nodes.
06/2012 - Start 16 rounds Navelbine and Herceptin weekly.
11/2012 - Liver resection, RFAs (8), lymphadenectomy (2), cholecystectomy.
12/2012 - Herceptin and Letrozole.
05/2014 - Mets: 5 aortocaval nodes & 1 mesenteric.
06/2014 - Herceptin/Perjeta/Taxotere - 6 rounds.
10/2014 - Herceptin / Perjeta - Open ended
04/2015 - Progression: Porta hepatic node, 2 aortocaval nodes.
05/2015 - Exploratory surgery treating progression, 12 nodes removed.
07/2015 - Restart Herceptin / Perjeta
01/2016 - Progression 8 nodes.
02/2016 - Starting T-DM1 (Kadcyla) - Open ended.
07/2017 - Progression.
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