Hi Rich,
Green tea (specifically EGCG) interferes with Velcade:
http://bloodjournal.hematologylibrar...nt/113/23/5927
That, of course, has nothing to do with us, but the pharmacists where I receive treatment (CINJ) recommend against any antioxidant supplementation during chemo under the theory that just as antioxidants protect healthy cells, they will also protect cancer cells by disrupting the free radicals produced by certain cancer drugs.
There are some studies for this idea (for and against), but I will have to search for them again (didn't save them when I did the initial search after the slash and burn on my supplement list), but the overall recommendations (which actually contradict the pharmacists to some extent) are on the Robert Wood Johnson site, here:
http://healthlibrary.epnet.com/GetCo...chunkiid=33802
Of course, my faith in the pharmacists was somewhat shaken by the fact that they did not caution me about the grandmother of all antioxidants--alpha lipoic acid--but I dropped that from my supplements on my own.
I tried to renegotiate some of my supplements after I was done with AC and moved on to Taxol and Herceptin, but it was put to me that I'm better safe than sorry. I did get a reluctant okay about SAM-e, but even that came with a caution. I'm still debating it, because it's great for the liver, and I need it for SAD now that winter's coming, but I'm seriously thinking about waiting until I'm done with Taxol. I'd rather have SAD for a couple of months than cancer for a (shortened) lifetime.
As an aside, the one antioxidant supplement I've increased (to prevent Taxol-induced neuropathy) is acetyl-l-carnitine. I've had two doses so far, and both my hands and feet are doing fine. There's a study for this also (ongoing, but promising, I believe), and having given up all the rest of the antioxidants on my list, I figured I was owed a compromise. ALCAR is a somewhat specialized antioxidant, though, so it shouldn't actually interfere the way the others might.
I'll get back to you on the other studies as soon as I have the mental fortitude to find them again. (Either that, or I'll do it the lazy way and ask the pharmacists for documentation next time I go for chemo.)
Edited to add: Here's one:
http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Citation