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Herceptin again after progression
Hi Sue
here's a link to another article on this topic. As I have said before, my oncologist told me flat out that after herceptin alone fails to keep the cancer at bay, you can get renewed synergy by just adding chemo back to the mix.
Re your other concern with liver function tests, my recent experience with the herceptin DM1 trial is that my liver function numbers have been (for the first time ever) consistently elevated, beginning with my first infusion of this drug, and fluctuate up and down a lot - the biggest jump being right after treatment, but then still bouncing around after that. This is clearly drug related and seems to just show that my liver is working very hard processing this medication. So this could be what's happening with you - you are on a new treatment, so your body may just be handling it differently than it did with other therapies. The fact that you say it is "all over the board" sounds more like that than an indicator of progression.
Hope this helps
http://www.pubmedcentral.nih.gov/art...?artid=1431554
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Chris in Scotts Valley
June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?"
9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++
10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response!
04/05 - 4/07 Herception every 3 wks, Continue NED
04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial
06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin
01/08 Progression in liver
02/08 Begin (TDM1) trial
08/08 NED! It's Working! Continue on TDM1
02/09 Continue NED
02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED
12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver
07/11 - 11/11 Herceptin/Xeloda -not working:(
12/11 Begin MM302 Phase I trial - bust:(
03/12 3rd times the charm? AKT trial
5/12 Scan shows reduction! 7/12 More reduction!!!!
8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!)
9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3
11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc
11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go.
2/13 Gemzar/Carbo/Herceptin - no go.
3/13 TACE procedure
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