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T,
I believe the most accurate test to determine whether treatment is working is a PET/CT scan. I had one at the time of initial diagnosis and then another at the end of chemo and before radiation. Thankfully, for me the chemo destroyed the 2 small infra-clavicular tumors I still had following surgery (I was Stage IIIC), and I am NED since then (June 2006). The tumor markers are called CA 27/29, although these are not completely reliable. Herceptin is a great drug - see Andi's (Andrea) amazing story in earlier posts. Yes, the uncertainty we all face can be overwhelming, but you just need to put one foot in front of the other, one step at a time, and move through your treatments - there is light at the end of the tunnel! Do lots of research so you can understand your options. I will be happy to try to help if I can - I work in the pharmaceutical industry and sometimes I actually hear of new things before my doctor.
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