Actually I was not in the right mood (long story) when I posted and did not like the sounds of a one man company called h2rc corporation..
but looking at it a bit more there is quite a lot to Oleuropein from other research, thanks Rich for the pub med which I usually would have checked but like I said was in a strange mood. I will get the paper and see what dose they used for mice, which is a poor indication but still an indication.. And yes I agreed with you too that many unpatentable/non synthec'able' are not studied.
Yes I will ask my friend to bring more she was told that I should take it along grape seed extract.
Oleuropein is particularly good for her2:
http://www.ncbi.nlm.nih.gov/pmc/arti...4/?tool=pubmed
Menendez et al. [53] showed that oleuropein aglycone is the most potent phenolic compound in decreasing breast cancer cell viability. HER2 oncogene-amplified SKBR3 cells were ∼5-times more sensitive to oleuropein aglycone than HER2-negative MCF-7 cells.
Subsequently, Menendez et al. [54] showed that the secoiridoids deacetoxy oleuropein aglycone, ligstroside aglycone, and oleuropein aglycone,
induce strong tumoricidal effects within a micromolar range by selectively triggering high levels of apoptotic cell death in HER2-overexpressing breast carcinomas. These compounds markedly depleted HER2 protein and reduced HER2 tyrosine autophosphorylation in a dose- and time-dependent manner [54].
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35 y/o
June 06: BC stage I
Grade 3; ER/PR neg
Her-2+++; lumpectomies
Aug 06: Stage IV
liver mets: 6 tumours
July 06 to Jan 07: 2*FEC+6*Taxotere; 3*TACE; LITT
March 07- Sept 07: Vaccination trial (phase 2, peptide based) at the UW (Seattle).
Herceptin since 2006
NED til Oct 09
Recurrence Oct 2009:
to internal mammary gland since October 2009 missed on Oct and March 2010 scan.. palpable nodes in May 2010 when I realised..
Nov 2011:7 mets to lungs progressing fast failed hercp/tykerb/xeloda combo..
superior vena cava blocked: stent but face remains puffy
April 2012: Teresa Trial, randomised to TDM1
Nov 2012 progressing on TDM1
Dec 2012 blockage of my airways by tumours, obliteration of these blocking tumours breathing better but hoping for more- at mo too many tumours to count in the lungs and nodes.
Dec 2012 Starting new trial S-222611 phase 1b dual egfr her2+ inhibitor.
'Under no circumstances should you lose hope..' Dalai Lama