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Old 08-02-2008, 08:00 PM   #17
hutchibk
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Join Date: Oct 2005
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MJP - when you click on the Herceptin/Tykerb forum, look towards the top of the page right underneath (Herceptin / Tykerb - Share your experiences or ask questions about Herceptin or Tykerb). There is a blue button that says "NEW THREAD" - click on that and you can start a new thread, titled with any title you think will draw attention to your question...
Hope that helps. YOU ARE NOT USELESS! Geez, don't make me kick your booty...

Anyway - Tykerb does not typically affect your blood count directly when it comes to RBC and WBC, it is typically any chemo that you might take with it that can run down those counts... That said, I have been on Tykerb with the chemo, Xeloda, for 15 months and have strong and normal RBC and WBC. Xeloda does not beat up my blood system at all.

My doc has told me that if we are to get results from PET, CT or MRI that shows anything new in the body or the organs, then we will add Herceptin in with my Tykerb (and I assume I will stay on the Xeloda as well, but maybe not.) I think the direction of thinking these days is that combining the targeted agents (Tykerb/Herceptin and maybe pertuzamab, the new one they are working on) is the possible key to closing all the pathways {especially and including HER1, HER3 and HER4} that HER2 cells use to escape. A combined approach of these targeted agents is suspected to hopefully put HER2 into submission. We are all hoping so. But they have figure out how to combine all three together in a way that our bodies can tolerate... but for now, we have only the first two, Tykerb and Herceptin, so that is what they are trying on some of us who progress beyond Herceptin/Chemo. That combo is showing some promise at this point... but research shows that we probably need a third agent in the combo to seal the deal... And so it goes.

Let us know what your scans say.
__________________
Brenda

NOV 2012 - 9 yr anniversary
JULY 2012 - 7 yr anniversary stage IV (of 50...)

Nov'03~ dX stage 2B
Dec'03~
Rt side mastectomy, Her2+, ER/PR+, 10 nodes out, one node positive
Jan'04~
Taxotere/Adria/Cytoxan x 6, NED, no Rads, Tamox. 1 year, Arimadex 3 mo., NED 14 mo.
Sept'05~
micro mets lungs/chest nodes/underarm node, Switched to Aromasin, T/C/H x 7, NED 6 months - Herceptin only
Aug'06~
micro mets chest nodes, & bone spot @ C3 neck, Added Taxol to Herceptin
Feb'07~ Genetic testing, BRCA 1&2 neg

Apr'07~
MRI - two 9mm brain mets & 5 punctates, new left chest met, & small increase of bone spot C3 neck, Stopped Aromasin
May'07~
Started Tykerb/Xeloda, no WBR for now
June'07~
MRI - stable brain mets, no new mets, 9mm spots less enhanced, CA15.3 down 45.5 to 9.3 in 10 wks, Ty/Xel working magic!
Aug'07~
MRI - brain mets shrunk half, NO NEW BRAIN METS!!, TMs stable @ 9.2
Oct'07~
PET/CT & MRI show NED
Apr'08~
scans still show NED in the head, small bone spot on right iliac crest (rear pelvic bone)
Sept'08~
MRI shows activity in brain mets, completed 5 fractions/5 consecutive days of IMRT to zap the pesky buggers
Oct'08~
dropped Xeloda, switched to tri-weekly Herceptin in combo with Tykerb, extend to tri-monthly Zometa infusion
Dec'08~
Brain MRI- 4 spots reduced to punctate size, large spot shrunk by 3mm, CT of torso clear/pelvis spot stable
June'09~
new 3-4mm left cerrebellar spot zapped with IMRT targeted rads
Sept'09~
new 6mm & 1 cm spots in pituitary/optic chiasm area. Rx= 25 days of 3D conformal fractionated targeted IMRT to the tumors.
Oct'09~
25 days of low dose 3D conformal fractionated targeted IMRT to the bone mets spot on rt. iliac crest that have been watching for 2 years. Added daily Aromasin back into treatment regimen.
Apr'10~ Brain MRI clear! But, see new small spot on adrenal gland. Change from Aromasin back to Tamoxifen.
June'10~ Tumor markers (CA15.3) dropped from 37 to 23 after one month on Tamoxifen. Continue to monitor adrenal gland spot. Remain on Tykerb/Herceptin/Tamoxifen.
Nov'10~ Radiate positive mediastinal node that was pressing on recurrent laryngeal nerve, causing paralyzed larynx and a funny voice.
Jan'11~ MRI shows possible activity or perhaps just scar tissue/necrotic increase on 3 previously treated brain spots and a pituitary spot. 5 days of IMRT on 4 spots.
Feb'11~ Enrolled in T-DM1 EAP in Denver, first treatment March 25, 2011.
Mar'11~ Finally started T-DM1 EAP in Denver at Rocky Mountain Cancer Center/Rose on Mar. 25... hallelujah.

"I would rather be anecdotally alive than statistically dead."

Last edited by hutchibk; 08-02-2008 at 08:04 PM.. Reason: add info
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