Thread: Mets to jaw?
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Old 05-06-2011, 04:20 PM   #5
Jackie07
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Re: Mets to jaw?

Emelie,

I'm sorry for your suffering. This breast cancer business is just no fun at all.

Through PubMed, I found several articles (abstracts) about the issue. The explanation of the side effect from bc treatment makes sense to me. But we can never be too careful. Hope the abstract below will calm your nerves a little bit...

Gan To Kagaku Ryoho. 2010 Sep;37(9):1791-3.
[A case of bisphosphonate-associated osteonecrosis of the jaw in a patient with bone metastasis of breast cancer].

[Article in Japanese]
Iimura Y, Kaneko H, Hasegawa N, Takahashi Y, Shoji Y, Kawabata M.
Source

Dept. of Surgery, Kushiro City General Hospital, Japan.

Abstract

A 5 6-year-old woman underwent modified radical mastectomy for left breast cancer in 2002. Bone metastases developed in November 2005, and she received pamidronate from February 2006. Pamidronate was changed to zoledronate in November 2006. In November 2007, she was referred to a dentist for pain and swelling of the right lower gum. Conservative therapy with local irrigation and antibiotics was performed, but the lesion progressed and showed ulceration with exposed bone. She was diagnosed as bisphosphonate-associated osteonecrosis of the jaws, and zoledronate was withdrawn in January 2008. Conservative therapy was continued but the necrotic lesion caused pathological fracture and fistula. In February 2009, surgical intervention was performed for the improvement of her QOL.
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