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Lani · 11-06-2006, 01:14 PM

"Our data indicates that GPR30 promotes tumor growth and is linked to metastatic disease, but also evidences GPR30's autonomy from the standard estrogen receptors," says Filardo. " It strengthens the concept that GPR30 and standard estrogen receptors promote distinct biological responses and invokes a new paradigm regarding our current understanding of breast cancer biology."

The authors note although GPR30 was strongly associated with the development of metastatic disease, there was not a connection between the presence of GPR30 and if breast cancer cells had invaded the lymph nodes of a patient.

"Further research is needed to determine if there is a relationship between GPR30 and lymph node invasion," says Filardo. "Given that tumor size and lymph node invasion are well-known predictors of metastases, future studies will focus on determining how cells that test positive for GPR30 spread throughout the body."

The research team also includes Carl Graeber, Murray Resnick, MD, Dilip Giri, MD, Ronald DeLellis, MD, Rhode Island Hospital and Brown Medical School; and Margaret Steinhoff, MD, Women and Infants Hospital and Brown Medical School.

The National Center for Research Resources, a component of the National Institutes of Health, funded the work.

11-06-2006, 01:14 PM	#3
Lani Senior Member Join Date: Mar 2006 Posts: 4,778	And More... "Our data indicates that GPR30 promotes tumor growth and is linked to metastatic disease, but also evidences GPR30's autonomy from the standard estrogen receptors," says Filardo. " It strengthens the concept that GPR30 and standard estrogen receptors promote distinct biological responses and invokes a new paradigm regarding our current understanding of breast cancer biology." The authors note although GPR30 was strongly associated with the development of metastatic disease, there was not a connection between the presence of GPR30 and if breast cancer cells had invaded the lymph nodes of a patient. "Further research is needed to determine if there is a relationship between GPR30 and lymph node invasion," says Filardo. "Given that tumor size and lymph node invasion are well-known predictors of metastases, future studies will focus on determining how cells that test positive for GPR30 spread throughout the body." The research team also includes Carl Graeber, Murray Resnick, MD, Dilip Giri, MD, Ronald DeLellis, MD, Rhode Island Hospital and Brown Medical School; and Margaret Steinhoff, MD, Women and Infants Hospital and Brown Medical School. The National Center for Research Resources, a component of the National Institutes of Health, funded the work.