HER2 Support Group Forums - View Single Post - taken off Taxotere..trying to remain positive

chrisy · 06-26-2012, 05:58 PM

Sheila,

I'm hoping for pertuzumab for you of course...but here's some other thoughts.
I still think you might want to see if you can get a chemosensitivity test on your tumor, although it seems to me largely skin mets, you may still be able to get a biopsy. And maybe go see dr block. They could arrange for that there if your doc isn't interested. Sometimes a chemosensitivity test can id combinations that worked, even with individual drugs that failed.

Speaking if drugs, I dont see ixempra on your list? Could you have missed that one? I remember dr Perez talking about that one at SABCS a few years ago. It was so fun to hear her say Ixabepilone - and she was quite keen on it.

Finally, you might thnk about tdm1 again assuming it gets approved soon ((not waiting for it of course, just a light of hope for the next step) because as you have said, it partly worked for you so may be worth another try.

You know I'm sending hugs and good vibes my dear friend. Hang in there.

06-26-2012, 05:58 PM	#7
chrisy Senior Member Join Date: Sep 2005 Location: Central Coast, CA Posts: 3,207	Re: taken off Taxotere..trying to remain positive Sheila, I'm hoping for pertuzumab for you of course...but here's some other thoughts. I still think you might want to see if you can get a chemosensitivity test on your tumor, although it seems to me largely skin mets, you may still be able to get a biopsy. And maybe go see dr block. They could arrange for that there if your doc isn't interested. Sometimes a chemosensitivity test can id combinations that worked, even with individual drugs that failed. Speaking if drugs, I dont see ixempra on your list? Could you have missed that one? I remember dr Perez talking about that one at SABCS a few years ago. It was so fun to hear her say Ixabepilone - and she was quite keen on it. Finally, you might thnk about tdm1 again assuming it gets approved soon ((not waiting for it of course, just a light of hope for the next step) because as you have said, it partly worked for you so may be worth another try. You know I'm sending hugs and good vibes my dear friend. Hang in there. __________________ Chris in Scotts Valley June 2002 extensive hi grade DCIS (pre-cancer-stage 0, clean sentinal node) Mastectomy/implant - no chemo, rads. "cured?" 9/2004 Diag: Stage IV extensive liver mets (!) ER/PR- Her2+++ 10/04-3/05 Weekly Taxol/Carboplatin/Herceptin , complete response! 04/05 - 4/07 Herception every 3 wks, Continue NED 04/07 - recurrence to liver - 2 spots, starting tykerb/avastin trial 06/07 8/07 10/07 Scans show stable, continue on Tykerb/Avastin 01/08 Progression in liver 02/08 Begin (TDM1) trial 08/08 NED! It's Working! Continue on TDM1 02/09 Continue NED 02/10 Continue NED. 5/10 9/10 Scans NED 10/10 Scans NED 12/10 Scans not clear....4/11 Scans suggest progression 6/11 progression confirmed in liver 07/11 - 11/11 Herceptin/Xeloda -not working:( 12/11 Begin MM302 Phase I trial - bust:( 03/12 3rd times the charm? AKT trial 5/12 Scan shows reduction! 7/12 More reduction!!!! 8/12 Whoops...progression...trying for Perjeta/Herceptin (plus some more nasty chemo!) 9/12 Start Perjeta/Herceptin, chemo on hold due to infection/wound in leg, added on cycle 2 &3 11/12 Poops! progression in liver, Stop Perjeta/Taxo/Herc 11/12 Navelbine/Herce[ptin - try for a 3 cycles, no go. 2/13 Gemzar/Carbo/Herceptin - no go. 3/13 TACE procedure