HER2 Support Group Forums - View Single Post - Is this onc for real? Herceptin weekly/everythree weeks trials

Christine MH-UK · 10-03-2005, 01:49 PM

I got worried, so I looked in PubMed and found this article by Dr Pegram
http://www.ncbi.nlm.nih.gov/entrez/q...791&query_hl=5

Which says "Although trastuzumab is currently usually administered on a weekly intravenous schedule, evidence suggests that a triple dose of the drug given once every three weeks has a pharmacokinetic profile expected to be equally efficacious. Neither the optimal schedule nor the optimal duration of trastuzumab therapy has yet been clearly defined in controlled clinical trials."

10-03-2005, 01:49 PM	#17
Christine MH-UK Senior Member Join Date: Sep 2005 Posts: 414	I got worried, so I looked in PubMed and found this article by Dr Pegram http://www.ncbi.nlm.nih.gov/entrez/q...791&query_hl=5 Which says "Although trastuzumab is currently usually administered on a weekly intravenous schedule, evidence suggests that a triple dose of the drug given once every three weeks has a pharmacokinetic profile expected to be equally efficacious. Neither the optimal schedule nor the optimal duration of trastuzumab therapy has yet been clearly defined in controlled clinical trials."