"DHA feeding increased its concentration from 2.3 to 7.4 wt% in the PBMNC total lipids, and decreased arachidonic acid concentration from 19.8 to 10.7 wt%. It also lowered prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production, in response to lipopolysaccharide, by 60-75%. Natural killer cell activity and in vitro secretion of interleukin-1beta and tumor necrosis factor alpha were significantly reduced by DHA feeding."
PGE2 is a percusor of aromatase which is a percusor of oestrogens.
So as a preventative in terms of oestrogen restriction DHA at higher doses may be a useful dietary additive. See previous post as to DHA fish oil dosages. Low dosages were reported as not showing the same effects.
Again omega six intake / reduction not examined to determine impact.
Please see posts on balancing omega threes and sixes.
Please do talk to youe medical advisor about significant dietary changes.
You can always think about printing the trials to take i to save you trying to explain. Any feed back positive or negative is most welcome.
RB
http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Abstract
1: Lipids. 1999 Apr;34(4):317-24. Related Articles, Links
Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men.
Kelley DS, Taylor PC, Nelson GJ, Schmidt PC, Ferretti A, Erickson KL, Yu R, Chandra RK, Mackey BE.
USDA, ARS, Western Human Nutrition Research Center, Presidio of San Francisco, California 94129, USA.
Dkelley@whnrc.usda.gov
The purpose of this study was to examine the effects of feeding docosahexaenoic acid (DHA) as triacylglycerol on the fatty acid composition, eicosanoid production, and select activities of human peripheral blood mononuclear cells (PBMNC). A 120-d study with 11 healthy men was conducted at the Metabolic Research Unit of Western Human Nutrition Reach Center. Four subjects (control group) were fed the stabilization diet throughout the study; the remaining seven subjects were fed the basal diet for the first 30 d, followed by 6 g DHA/d for the next 90 d. DHA replaced an equivalent amount of linoleic acid; the two diets were comparable in their total fat and all other nutrients. Both diets were supplemented with 20 mg D alpha-tocopherol acetate per day. PBMNC fatty acid composition and eicosanoid production were examined on day 30 and 113; immune cell functions were tested on day 22, 30, 78, 85, 106, and 113. DHA feeding increased its concentration from 2.3 to 7.4 wt% in the PBMNC total lipids, and decreased arachidonic acid concentration from 19.8 to 10.7 wt%. It also lowered prostaglandin E2 (PGE2) and leukotriene B4 (LTB4) production, in response to lipopolysaccharide, by 60-75%. Natural killer cell activity and in vitro secretion of interleukin-1beta and tumor necrosis factor alpha were significantly reduced by DHA feeding. These parameters remained unchanged in the subjects fed the control diet. B-cell functions as reported here and T-cell functions that we reported previously were not altered by DHA feeding. Our results show that inhibitory effects of DHA on immune cell functions varied with the cell type, and that the inhibitory effects are not mediated through increased production of PGE2 and LTB4.
Publication Types:
* Clinical Trial
PMID: 10443964 [PubMed - indexed for MEDLINE]
This is a link which sort of explains what a lippolysacceride is in this complex.
Something to get the prostaglandin out of bed (the membrane) and off to work (immune defence). If somebody can could confirm this it would be helpful.
http://en.wikipedia.org/wiki/Lipopolysaccharide