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Lani, this is interesting, as Letrozole (Femara) is a more potent suppressor of aromatase than Anastrazole (Arimidex). Could it be the metabolization of the drug, rather than the absolute value of circulating ER achieved, that is the difference? If so, it would mean a lot to those of us using topical estrogens to combat the side effects of the AIs.
Hopeful
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