HER2 Support Group Forums - View Single Post - Avastin Plus Commonly Used Chemotherapies Improved Progression-Free Survival in Advan

gdpawel · 12-10-2009, 06:28 AM

Actually, polyphenols found in red wine - such as resveratrol - are thought to have anti-oxidant or anti-cancer properties. Polyphenols are antioxidant compounds found in the skin and seeds of grapes. When wine is made from these grapes, the alcohol produced by the fermentation process dissolves the polyphenols contained in the skin and seeds. Red wine contains more polyphenols than white wine because the making of white wine requires the removal of the skins after the grapes are crushed.

What makes this interesting in cancer is the anti-angiogenic enhancer and potentiator effect of the alcohol in red wine. What it seems to tell us is that alcohol reduces the angiogenic secretions by the tumor cells. If it does that, it could both reduce these secretions and make an anti-angiogenesis drug less resistant to the tumor cells, making it more effective. In the presence of an anti-angiogenesis drug, you can have a lethel 1-2 combination which knocks out the new blood vessels which are dependent for survival of the cancer. Polyphenols extracted from red wine could be converted into a pill that is highly likely to be safe, relatively easy and inexpensive to create, and deliver (instead of one and a half bottles of red wine per day).

Resveratrol is a type of polyphenol called a phytoalexin, a class of compounds produced as part of a plant's defense system against disease. It is produced in the plant in response to an invading fungus, stress, injury, infection or ultraviolet irradiation. Red wine contains high levels of resveratrol, as do grapes, raspberries, peanuts and other plants.

Resveratrol has been shown to reduce tumor incidence in animals by affecting one or more stages of cancer development. It has been shown to inhibit growth of many types of cancer cells in cell culture. Evidence also exists that it can reduce inflammation. It also reduces activation of NF kappa B, a protein produced by the body's immune system when it is under attack. This protein affects cancer cell growth and metastasis. Resveratrol is also an antioxidant.

Many of the new gene-targeted drugs do not target enough genes. Cancer researchers now recognize hundreds if not thousands of genes must be down-regulated to conquer cancer. In one study, for example, at least 74 genes must be controlled in renal cancer alone (Cancer Biol Ther. 2004 Sep;3(9):889-90. Epub 2004 Sep 24). So-called promiscuous gene inhibitors must be found. A targeted drug like Sutent only down-regulates a small number of genes.

Resveratrol favorably switches many genes, and this has been shown in a renal cancer cell line (PMID: 15467424)(BMC Urol. 2004 Jun 22;4:9). It appears that resveratrol can target "all" genes involved in cancer. It is possible that it also chemosensitizes tumor cells, all the genes within the cell (a potentiator of chemotherapy drugs).

However, they did develope a new wine for seniors.

California vintners in the Napa Valley area, which primarily produces Pinot Blanc, Pinot Noir and Pinot Grigio wines, have developed a new hybrid grape that acts as an anti-diuretic.

It is expected to reduce the number of trips older people have to make to the bathroom during the night.

The new wine will be marketed as...

PINO MORE.

I heard this through the grapevine

12-10-2009, 06:28 AM	#4
gdpawel Senior Member Join Date: Aug 2006 Location: Pennsylvania Posts: 1,080	The alcohol in red wine Actually, polyphenols found in red wine - such as resveratrol - are thought to have anti-oxidant or anti-cancer properties. Polyphenols are antioxidant compounds found in the skin and seeds of grapes. When wine is made from these grapes, the alcohol produced by the fermentation process dissolves the polyphenols contained in the skin and seeds. Red wine contains more polyphenols than white wine because the making of white wine requires the removal of the skins after the grapes are crushed. What makes this interesting in cancer is the anti-angiogenic enhancer and potentiator effect of the alcohol in red wine. What it seems to tell us is that alcohol reduces the angiogenic secretions by the tumor cells. If it does that, it could both reduce these secretions and make an anti-angiogenesis drug less resistant to the tumor cells, making it more effective. In the presence of an anti-angiogenesis drug, you can have a lethel 1-2 combination which knocks out the new blood vessels which are dependent for survival of the cancer. Polyphenols extracted from red wine could be converted into a pill that is highly likely to be safe, relatively easy and inexpensive to create, and deliver (instead of one and a half bottles of red wine per day). Resveratrol is a type of polyphenol called a phytoalexin, a class of compounds produced as part of a plant's defense system against disease. It is produced in the plant in response to an invading fungus, stress, injury, infection or ultraviolet irradiation. Red wine contains high levels of resveratrol, as do grapes, raspberries, peanuts and other plants. Resveratrol has been shown to reduce tumor incidence in animals by affecting one or more stages of cancer development. It has been shown to inhibit growth of many types of cancer cells in cell culture. Evidence also exists that it can reduce inflammation. It also reduces activation of NF kappa B, a protein produced by the body's immune system when it is under attack. This protein affects cancer cell growth and metastasis. Resveratrol is also an antioxidant. Many of the new gene-targeted drugs do not target enough genes. Cancer researchers now recognize hundreds if not thousands of genes must be down-regulated to conquer cancer. In one study, for example, at least 74 genes must be controlled in renal cancer alone (Cancer Biol Ther. 2004 Sep;3(9):889-90. Epub 2004 Sep 24). So-called promiscuous gene inhibitors must be found. A targeted drug like Sutent only down-regulates a small number of genes. Resveratrol favorably switches many genes, and this has been shown in a renal cancer cell line (PMID: 15467424)(BMC Urol. 2004 Jun 22;4:9). It appears that resveratrol can target "all" genes involved in cancer. It is possible that it also chemosensitizes tumor cells, all the genes within the cell (a potentiator of chemotherapy drugs). However, they did develope a new wine for seniors. California vintners in the Napa Valley area, which primarily produces Pinot Blanc, Pinot Noir and Pinot Grigio wines, have developed a new hybrid grape that acts as an anti-diuretic. It is expected to reduce the number of trips older people have to make to the bathroom during the night. The new wine will be marketed as... PINO MORE. I heard this through the grapevine